Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line

Here, we present the first in silico and in vitro evidence of Aβ-like peptides released from meaningful members of the gut microbiome (mostly from the Clostridiales order). Two peptides with high homology to the human Aβ peptide domain were synthesized and tested in vitro in a neuron cell-line model...

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Autores principales:	Aitor Blanco-Míguez, Hector Tamés, Patricia Ruas-Madiedo, Borja Sánchez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease human gut microbiota β-amyloid-like peptides Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/9c71e6fdd3a54fb591c54c5cd9b4b92a
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spelling	oai:doaj.org-article:9c71e6fdd3a54fb591c54c5cd9b4b92a2021-11-25T18:34:47ZMicrobiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line10.3390/nu131138682072-6643https://doaj.org/article/9c71e6fdd3a54fb591c54c5cd9b4b92a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3868https://doaj.org/toc/2072-6643Here, we present the first in silico and in vitro evidence of Aβ-like peptides released from meaningful members of the gut microbiome (mostly from the Clostridiales order). Two peptides with high homology to the human Aβ peptide domain were synthesized and tested in vitro in a neuron cell-line model. Gene expression profile analysis showed that one of them induced whole gene pathways related to AD, opening the way to translational approaches to assess whether gut microbiota-derived peptides might be implicated in the neurodegenerative processes related to AD. This exploratory work opens the path to new approaches for understanding the relationship between the gut microbiome and the triggering of potential molecular events leading to AD. As microbiota can be modified using diet, tools for precise nutritional intervention or targeted microbiota modification in animal models might help us to understand the individual roles of gut bacteria releasing Aβ-like peptides and therefore their contribution to this progressive disease.Aitor Blanco-MíguezHector TamésPatricia Ruas-MadiedoBorja SánchezMDPI AGarticleAlzheimer’s diseasehuman gut microbiotaβ-amyloid-like peptidesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3868, p 3868 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease human gut microbiota β-amyloid-like peptides Nutrition. Foods and food supply TX341-641
spellingShingle	Alzheimer’s disease human gut microbiota β-amyloid-like peptides Nutrition. Foods and food supply TX341-641 Aitor Blanco-Míguez Hector Tamés Patricia Ruas-Madiedo Borja Sánchez Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line
description	Here, we present the first in silico and in vitro evidence of Aβ-like peptides released from meaningful members of the gut microbiome (mostly from the Clostridiales order). Two peptides with high homology to the human Aβ peptide domain were synthesized and tested in vitro in a neuron cell-line model. Gene expression profile analysis showed that one of them induced whole gene pathways related to AD, opening the way to translational approaches to assess whether gut microbiota-derived peptides might be implicated in the neurodegenerative processes related to AD. This exploratory work opens the path to new approaches for understanding the relationship between the gut microbiome and the triggering of potential molecular events leading to AD. As microbiota can be modified using diet, tools for precise nutritional intervention or targeted microbiota modification in animal models might help us to understand the individual roles of gut bacteria releasing Aβ-like peptides and therefore their contribution to this progressive disease.
format	article
author	Aitor Blanco-Míguez Hector Tamés Patricia Ruas-Madiedo Borja Sánchez
author_facet	Aitor Blanco-Míguez Hector Tamés Patricia Ruas-Madiedo Borja Sánchez
author_sort	Aitor Blanco-Míguez
title	Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line
title_short	Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line
title_full	Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line
title_fullStr	Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line
title_full_unstemmed	Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line
title_sort	microbiota-derived β-amyloid-like peptides trigger alzheimer’s disease-related pathways in the sh-sy5y neural cell line
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9c71e6fdd3a54fb591c54c5cd9b4b92a
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Microbiota-Derived β-Amyloid-like Peptides Trigger Alzheimer’s Disease-Related Pathways in the SH-SY5Y Neural Cell Line

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