Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family

Bone morphogenetic proteins (BMPs) are potent signaling molecules initially described as osteopromoting proteins. BMPs represent one of the members of the larger TGFβ family and today are recognized for their important role in numerous processes. Among the wide array of functions recently attributed...

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Autores principales:	Tommaso Sconocchia, Giuseppe Sconocchia
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	BMP cancer inflammation immune regulation autoimmunity dendritic cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9c73e66158a14da797415da73226be0d
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spelling	oai:doaj.org-article:9c73e66158a14da797415da73226be0d2021-12-02T09:04:58ZRegulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family1664-322410.3389/fimmu.2021.802346https://doaj.org/article/9c73e66158a14da797415da73226be0d2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.802346/fullhttps://doaj.org/toc/1664-3224Bone morphogenetic proteins (BMPs) are potent signaling molecules initially described as osteopromoting proteins. BMPs represent one of the members of the larger TGFβ family and today are recognized for their important role in numerous processes. Among the wide array of functions recently attributed to them, BMPs were also described to be involved in the regulation of components of the innate and adaptive immune response. This review focuses on the signaling pathway of BMPs and highlights the effects of BMP signaling on the differentiation, activation, and function of the main cell types of the immune system.Tommaso SconocchiaGiuseppe SconocchiaFrontiers Media S.A.articleBMPcancerinflammationimmune regulationautoimmunitydendritic cellsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BMP cancer inflammation immune regulation autoimmunity dendritic cells Immunologic diseases. Allergy RC581-607
spellingShingle	BMP cancer inflammation immune regulation autoimmunity dendritic cells Immunologic diseases. Allergy RC581-607 Tommaso Sconocchia Giuseppe Sconocchia Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family
description	Bone morphogenetic proteins (BMPs) are potent signaling molecules initially described as osteopromoting proteins. BMPs represent one of the members of the larger TGFβ family and today are recognized for their important role in numerous processes. Among the wide array of functions recently attributed to them, BMPs were also described to be involved in the regulation of components of the innate and adaptive immune response. This review focuses on the signaling pathway of BMPs and highlights the effects of BMP signaling on the differentiation, activation, and function of the main cell types of the immune system.
format	article
author	Tommaso Sconocchia Giuseppe Sconocchia
author_facet	Tommaso Sconocchia Giuseppe Sconocchia
author_sort	Tommaso Sconocchia
title	Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family
title_short	Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family
title_full	Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family
title_fullStr	Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family
title_full_unstemmed	Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family
title_sort	regulation of the immune system in health and disease by members of the bone morphogenetic protein family
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9c73e66158a14da797415da73226be0d
work_keys_str_mv	AT tommasosconocchia regulationoftheimmunesysteminhealthanddiseasebymembersofthebonemorphogeneticproteinfamily AT giuseppesconocchia regulationoftheimmunesysteminhealthanddiseasebymembersofthebonemorphogeneticproteinfamily
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Regulation of the Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family

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