Inherited determinants of early recurrent somatic mutations in prostate cancer

Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone dependent DNA damage response.

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Autores principales:	Alessandro Romanel, Sonia Garritano, Blerta Stringa, Mirjam Blattner, Davide Dalfovo, Dimple Chakravarty, David Soong, Kellie A. Cotter, Gianluca Petris, Priyanka Dhingra, Paola Gasperini, Anna Cereseto, Olivier Elemento, Andrea Sboner, Ekta Khurana, Alberto Inga, Mark A. Rubin, Francesca Demichelis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c76b74b1a9c4adba882a4b50f1bdddc
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spelling	oai:doaj.org-article:9c76b74b1a9c4adba882a4b50f1bdddc2021-12-02T13:57:44ZInherited determinants of early recurrent somatic mutations in prostate cancer10.1038/s41467-017-00046-02041-1723https://doaj.org/article/9c76b74b1a9c4adba882a4b50f1bdddc2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00046-0https://doaj.org/toc/2041-1723Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone dependent DNA damage response.Alessandro RomanelSonia GarritanoBlerta StringaMirjam BlattnerDavide DalfovoDimple ChakravartyDavid SoongKellie A. CotterGianluca PetrisPriyanka DhingraPaola GasperiniAnna CeresetoOlivier ElementoAndrea SbonerEkta KhuranaAlberto IngaMark A. RubinFrancesca DemichelisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Romanel Sonia Garritano Blerta Stringa Mirjam Blattner Davide Dalfovo Dimple Chakravarty David Soong Kellie A. Cotter Gianluca Petris Priyanka Dhingra Paola Gasperini Anna Cereseto Olivier Elemento Andrea Sboner Ekta Khurana Alberto Inga Mark A. Rubin Francesca Demichelis Inherited determinants of early recurrent somatic mutations in prostate cancer
description	Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone dependent DNA damage response.
format	article
author	Alessandro Romanel Sonia Garritano Blerta Stringa Mirjam Blattner Davide Dalfovo Dimple Chakravarty David Soong Kellie A. Cotter Gianluca Petris Priyanka Dhingra Paola Gasperini Anna Cereseto Olivier Elemento Andrea Sboner Ekta Khurana Alberto Inga Mark A. Rubin Francesca Demichelis
author_facet	Alessandro Romanel Sonia Garritano Blerta Stringa Mirjam Blattner Davide Dalfovo Dimple Chakravarty David Soong Kellie A. Cotter Gianluca Petris Priyanka Dhingra Paola Gasperini Anna Cereseto Olivier Elemento Andrea Sboner Ekta Khurana Alberto Inga Mark A. Rubin Francesca Demichelis
author_sort	Alessandro Romanel
title	Inherited determinants of early recurrent somatic mutations in prostate cancer
title_short	Inherited determinants of early recurrent somatic mutations in prostate cancer
title_full	Inherited determinants of early recurrent somatic mutations in prostate cancer
title_fullStr	Inherited determinants of early recurrent somatic mutations in prostate cancer
title_full_unstemmed	Inherited determinants of early recurrent somatic mutations in prostate cancer
title_sort	inherited determinants of early recurrent somatic mutations in prostate cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c76b74b1a9c4adba882a4b50f1bdddc
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Inherited determinants of early recurrent somatic mutations in prostate cancer

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