TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a member of the pseudokinase family, tribbles homologue 3 (TRIB3), interacts with c-MYC to suppress c-MYC ubiquitination and degradation, leading to increased proliferation and self-renewal of lymphoma cells...

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Autores principales:	Ke Li, Feng Wang, Zhao-na Yang, Ting-ting Zhang, Yu-fen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiao-xi Lv, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Jin-mei Yu, Shuang Shang, Yang Xiao, Zhuo-wei Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c78c5b2b4e747f5a5bbf0ce19770f93
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spelling	oai:doaj.org-article:9c78c5b2b4e747f5a5bbf0ce19770f932021-12-02T10:48:00ZTRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation10.1038/s41467-020-20107-12041-1723https://doaj.org/article/9c78c5b2b4e747f5a5bbf0ce19770f932020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20107-1https://doaj.org/toc/2041-1723c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a member of the pseudokinase family, tribbles homologue 3 (TRIB3), interacts with c-MYC to suppress c-MYC ubiquitination and degradation, leading to increased proliferation and self-renewal of lymphoma cells.Ke LiFeng WangZhao-na YangTing-ting ZhangYu-fen YuanChen-xi ZhaoZaiwuli YeerjiangBing CuiFang HuaXiao-xi LvXiao-wei ZhangJiao-jiao YuShan-shan LiuJin-mei YuShuang ShangYang XiaoZhuo-wei HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ke Li Feng Wang Zhao-na Yang Ting-ting Zhang Yu-fen Yuan Chen-xi Zhao Zaiwuli Yeerjiang Bing Cui Fang Hua Xiao-xi Lv Xiao-wei Zhang Jiao-jiao Yu Shan-shan Liu Jin-mei Yu Shuang Shang Yang Xiao Zhuo-wei Hu TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
description	c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a member of the pseudokinase family, tribbles homologue 3 (TRIB3), interacts with c-MYC to suppress c-MYC ubiquitination and degradation, leading to increased proliferation and self-renewal of lymphoma cells.
format	article
author	Ke Li Feng Wang Zhao-na Yang Ting-ting Zhang Yu-fen Yuan Chen-xi Zhao Zaiwuli Yeerjiang Bing Cui Fang Hua Xiao-xi Lv Xiao-wei Zhang Jiao-jiao Yu Shan-shan Liu Jin-mei Yu Shuang Shang Yang Xiao Zhuo-wei Hu
author_facet	Ke Li Feng Wang Zhao-na Yang Ting-ting Zhang Yu-fen Yuan Chen-xi Zhao Zaiwuli Yeerjiang Bing Cui Fang Hua Xiao-xi Lv Xiao-wei Zhang Jiao-jiao Yu Shan-shan Liu Jin-mei Yu Shuang Shang Yang Xiao Zhuo-wei Hu
author_sort	Ke Li
title	TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
title_short	TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
title_full	TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
title_fullStr	TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
title_full_unstemmed	TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
title_sort	trib3 promotes myc-associated lymphoma development through suppression of ube3b-mediated myc degradation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9c78c5b2b4e747f5a5bbf0ce19770f93
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TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

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