TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a member of the pseudokinase family, tribbles homologue 3 (TRIB3), interacts with c-MYC to suppress c-MYC ubiquitination and degradation, leading to increased proliferation and self-renewal of lymphoma cells...
Guardado en:
Autores principales: | Ke Li, Feng Wang, Zhao-na Yang, Ting-ting Zhang, Yu-fen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiao-xi Lv, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Jin-mei Yu, Shuang Shang, Yang Xiao, Zhuo-wei Hu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/9c78c5b2b4e747f5a5bbf0ce19770f93 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
por: Jiao-jiao Yu, et al.
Publicado: (2020) -
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
por: Jin-mei Yu, et al.
Publicado: (2019) -
MYC as therapeutic target in leukemia and lymphoma
por: Cortiguera MG, et al.
Publicado: (2015) -
Cross-talk between Myc and p53 in B-cell lymphomas
por: Li Yu, et al.
Publicado: (2019) -
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
por: Marcus Lefebure, et al.
Publicado: (2017)