Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

Abnormal alveolar development and homeostasis are common features of pulmonary disease. Here the authors show that Myh10 expression is reduced in emphysema patients, and that Myh10 loss of function impairs alveolar formation and lung morphogenesis via upregulation of matrix metalloproteinase activit...

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Autores principales:	Hyun-Taek Kim, Wenguang Yin, Young-June Jin, Paolo Panza, Felix Gunawan, Beate Grohmann, Carmen Buettner, Anna M. Sokol, Jens Preussner, Stefan Guenther, Sawa Kostin, Clemens Ruppert, Aditya M. Bhagwat, Xuefei Ma, Johannes Graumann, Mario Looso, Andreas Guenther, Robert S. Adelstein, Stefan Offermanns, Didier Y. R. Stainier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c82eaa0f78840cf96f7573a8ea8f76d
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spelling	oai:doaj.org-article:9c82eaa0f78840cf96f7573a8ea8f76d2021-12-02T15:34:25ZMyh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease10.1038/s41467-018-06833-72041-1723https://doaj.org/article/9c82eaa0f78840cf96f7573a8ea8f76d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06833-7https://doaj.org/toc/2041-1723Abnormal alveolar development and homeostasis are common features of pulmonary disease. Here the authors show that Myh10 expression is reduced in emphysema patients, and that Myh10 loss of function impairs alveolar formation and lung morphogenesis via upregulation of matrix metalloproteinase activity and altered matrix remodeling.Hyun-Taek KimWenguang YinYoung-June JinPaolo PanzaFelix GunawanBeate GrohmannCarmen BuettnerAnna M. SokolJens PreussnerStefan GuentherSawa KostinClemens RuppertAditya M. BhagwatXuefei MaJohannes GraumannMario LoosoAndreas GuentherRobert S. AdelsteinStefan OffermannsDidier Y. R. StainierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyun-Taek Kim Wenguang Yin Young-June Jin Paolo Panza Felix Gunawan Beate Grohmann Carmen Buettner Anna M. Sokol Jens Preussner Stefan Guenther Sawa Kostin Clemens Ruppert Aditya M. Bhagwat Xuefei Ma Johannes Graumann Mario Looso Andreas Guenther Robert S. Adelstein Stefan Offermanns Didier Y. R. Stainier Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
description	Abnormal alveolar development and homeostasis are common features of pulmonary disease. Here the authors show that Myh10 expression is reduced in emphysema patients, and that Myh10 loss of function impairs alveolar formation and lung morphogenesis via upregulation of matrix metalloproteinase activity and altered matrix remodeling.
format	article
author	Hyun-Taek Kim Wenguang Yin Young-June Jin Paolo Panza Felix Gunawan Beate Grohmann Carmen Buettner Anna M. Sokol Jens Preussner Stefan Guenther Sawa Kostin Clemens Ruppert Aditya M. Bhagwat Xuefei Ma Johannes Graumann Mario Looso Andreas Guenther Robert S. Adelstein Stefan Offermanns Didier Y. R. Stainier
author_facet	Hyun-Taek Kim Wenguang Yin Young-June Jin Paolo Panza Felix Gunawan Beate Grohmann Carmen Buettner Anna M. Sokol Jens Preussner Stefan Guenther Sawa Kostin Clemens Ruppert Aditya M. Bhagwat Xuefei Ma Johannes Graumann Mario Looso Andreas Guenther Robert S. Adelstein Stefan Offermanns Didier Y. R. Stainier
author_sort	Hyun-Taek Kim
title	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
title_short	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
title_full	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
title_fullStr	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
title_full_unstemmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
title_sort	myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c82eaa0f78840cf96f7573a8ea8f76d
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Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

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