A high prevalence of extreme hyperferritinemia in acute hepatitis patients

Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, Masayuki Miyazaki, Masaki Kato, Motoyuki Kohjima, Munechika Enjoji, Makoto Nakamuta, Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, JapanAbstract: Although the mechanis...

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Autores principales:	Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/9c84138a0f4546c4ac7e36f091a8411b
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spelling	oai:doaj.org-article:9c84138a0f4546c4ac7e36f091a8411b2021-12-02T02:36:35ZA high prevalence of extreme hyperferritinemia in acute hepatitis patients1179-1535https://doaj.org/article/9c84138a0f4546c4ac7e36f091a8411b2009-09-01T00:00:00Zhttp://www.dovepress.com/a-high-prevalence-of-extreme-hyperferritinemia-in-acute-hepatitis-pati-a3545https://doaj.org/toc/1179-1535Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, Masayuki Miyazaki, Masaki Kato, Motoyuki Kohjima, Munechika Enjoji, Makoto Nakamuta, Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, JapanAbstract: Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF. &nbsp;Keywords: acute hepatitis, acute liver failure, ferritin, macrophage Kazuhiro KotohAkihiro UedaMasatake Tanakaet al.Dove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2009, Iss default, Pp 1-7 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Kazuhiro Kotoh Akihiro Ueda Masatake Tanaka et al. A high prevalence of extreme hyperferritinemia in acute hepatitis patients
description	Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, Masayuki Miyazaki, Masaki Kato, Motoyuki Kohjima, Munechika Enjoji, Makoto Nakamuta, Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, JapanAbstract: Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF. &nbsp;Keywords: acute hepatitis, acute liver failure, ferritin, macrophage
format	article
author	Kazuhiro Kotoh Akihiro Ueda Masatake Tanaka et al.
author_facet	Kazuhiro Kotoh Akihiro Ueda Masatake Tanaka et al.
author_sort	Kazuhiro Kotoh
title	A high prevalence of extreme hyperferritinemia in acute hepatitis patients
title_short	A high prevalence of extreme hyperferritinemia in acute hepatitis patients
title_full	A high prevalence of extreme hyperferritinemia in acute hepatitis patients
title_fullStr	A high prevalence of extreme hyperferritinemia in acute hepatitis patients
title_full_unstemmed	A high prevalence of extreme hyperferritinemia in acute hepatitis patients
title_sort	high prevalence of extreme hyperferritinemia in acute hepatitis patients
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/9c84138a0f4546c4ac7e36f091a8411b
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A high prevalence of extreme hyperferritinemia in acute hepatitis patients

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