Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria

Mark Charbonneau et al. develop a mathematical model that describes the behavior of an engineered bacterial therapeutic, SYNB1618, in the human gastrointestinal tract and its effects on plasma phenylalanine (Phe) levels. This model enables the authors to predict plasma Phe lowering by SYNB1618 in pa...

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Autores principales:	Mark R. Charbonneau, William S. Denney, Nicholas G. Horvath, Pasquale Cantarella, Mary J. Castillo, Marja K. Puurunen, Aoife M. Brennan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9c842b6d19dd4ea5ab162237138ababd
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spelling	oai:doaj.org-article:9c842b6d19dd4ea5ab162237138ababd2021-12-02T16:17:32ZDevelopment of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria10.1038/s42003-021-02183-12399-3642https://doaj.org/article/9c842b6d19dd4ea5ab162237138ababd2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02183-1https://doaj.org/toc/2399-3642Mark Charbonneau et al. develop a mathematical model that describes the behavior of an engineered bacterial therapeutic, SYNB1618, in the human gastrointestinal tract and its effects on plasma phenylalanine (Phe) levels. This model enables the authors to predict plasma Phe lowering by SYNB1618 in patients with phenylketonuria.Mark R. CharbonneauWilliam S. DenneyNicholas G. HorvathPasquale CantarellaMary J. CastilloMarja K. PuurunenAoife M. BrennanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mark R. Charbonneau William S. Denney Nicholas G. Horvath Pasquale Cantarella Mary J. Castillo Marja K. Puurunen Aoife M. Brennan Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
description	Mark Charbonneau et al. develop a mathematical model that describes the behavior of an engineered bacterial therapeutic, SYNB1618, in the human gastrointestinal tract and its effects on plasma phenylalanine (Phe) levels. This model enables the authors to predict plasma Phe lowering by SYNB1618 in patients with phenylketonuria.
format	article
author	Mark R. Charbonneau William S. Denney Nicholas G. Horvath Pasquale Cantarella Mary J. Castillo Marja K. Puurunen Aoife M. Brennan
author_facet	Mark R. Charbonneau William S. Denney Nicholas G. Horvath Pasquale Cantarella Mary J. Castillo Marja K. Puurunen Aoife M. Brennan
author_sort	Mark R. Charbonneau
title	Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
title_short	Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
title_full	Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
title_fullStr	Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
title_full_unstemmed	Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
title_sort	development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c842b6d19dd4ea5ab162237138ababd
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Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria

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