The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults

Abstract To examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. A double-blind, randomised, placebo controlled trial to examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in...

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Autores principales:	Amanda Rao, David Briskey, Carla dos Reis, Alistair R. Mallard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c845db4a08d455284a50b69ae26cbcb
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spelling	oai:doaj.org-article:9c845db4a08d455284a50b69ae26cbcb2021-12-02T17:04:06ZThe effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults10.1038/s41598-021-86108-22045-2322https://doaj.org/article/9c845db4a08d455284a50b69ae26cbcb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86108-2https://doaj.org/toc/2045-2322Abstract To examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. A double-blind, randomised, placebo controlled trial to examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. Eighty-three men and women aged between 20 and 50 years of age completed 16 weeks of daily supplementation with either CFE or placebo. Plasma cardiometabolic (lipid profile, glucose, insulin) and satiety (ghrelin, leptin, neuropeptideY) biomarkers, body composition, diet history and gastrointenstinal function were assessed at baseline, weeks 4, 8, 12 and 16. Subjects in the CFE and placebo groups were well matched and predominatly female 93% and 87.5%, with a mean age of 40.9 ± 6.7 and 39.5 ± 7.5 years and body mass index (BMI) of 30.0 ± 3.1 and 30.2 ± 2.9 kg/m2 respectively. There was a significant difference in plasma leptin concentration change between groups at week 16 (p = 0.04), with the placebo group increasing concentration (2.27 ± 4.80 ng/mL) while the CFE group (0.05 ± 4.69 ng/mL) remained the same. At week 16, the CFE group had significantly reduced their calorie intake from baseline compared to the placebo group (245 cal vs 15.8 cal respectively p < 0.01). The CFE group also had a significant reduction in waist circumference of 2.7 cm compared to an increase of 0.3 cm in the placebo group (p = 0.02). A weight increase from baseline was seen in the placebo group that was not observed in the CFE group (1.33 kg weight gain vs 0.37 kg weight loss respectively; p = 0.03). The placebo group also had a significant increase in fat mass, android fat mass, BMI and leptin compared to the CFE group (p = 0.04, 0.02, < 0.01 respectively). CFE was effective at maintaining bodyweight during a non-calorie controlled diet compared to a placebo. The mechanism responsible for this action is requiring further research and could be due to an increase in satiety receptor sensitivity.Amanda RaoDavid BriskeyCarla dos ReisAlistair R. MallardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amanda Rao David Briskey Carla dos Reis Alistair R. Mallard The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults
description	Abstract To examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. A double-blind, randomised, placebo controlled trial to examine the effect of a Caralluma Fimbriata extract (CFE) on biomarkers of satiety and body composition in overweight adults. Eighty-three men and women aged between 20 and 50 years of age completed 16 weeks of daily supplementation with either CFE or placebo. Plasma cardiometabolic (lipid profile, glucose, insulin) and satiety (ghrelin, leptin, neuropeptideY) biomarkers, body composition, diet history and gastrointenstinal function were assessed at baseline, weeks 4, 8, 12 and 16. Subjects in the CFE and placebo groups were well matched and predominatly female 93% and 87.5%, with a mean age of 40.9 ± 6.7 and 39.5 ± 7.5 years and body mass index (BMI) of 30.0 ± 3.1 and 30.2 ± 2.9 kg/m2 respectively. There was a significant difference in plasma leptin concentration change between groups at week 16 (p = 0.04), with the placebo group increasing concentration (2.27 ± 4.80 ng/mL) while the CFE group (0.05 ± 4.69 ng/mL) remained the same. At week 16, the CFE group had significantly reduced their calorie intake from baseline compared to the placebo group (245 cal vs 15.8 cal respectively p < 0.01). The CFE group also had a significant reduction in waist circumference of 2.7 cm compared to an increase of 0.3 cm in the placebo group (p = 0.02). A weight increase from baseline was seen in the placebo group that was not observed in the CFE group (1.33 kg weight gain vs 0.37 kg weight loss respectively; p = 0.03). The placebo group also had a significant increase in fat mass, android fat mass, BMI and leptin compared to the CFE group (p = 0.04, 0.02, < 0.01 respectively). CFE was effective at maintaining bodyweight during a non-calorie controlled diet compared to a placebo. The mechanism responsible for this action is requiring further research and could be due to an increase in satiety receptor sensitivity.
format	article
author	Amanda Rao David Briskey Carla dos Reis Alistair R. Mallard
author_facet	Amanda Rao David Briskey Carla dos Reis Alistair R. Mallard
author_sort	Amanda Rao
title	The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults
title_short	The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults
title_full	The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults
title_fullStr	The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults
title_full_unstemmed	The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults
title_sort	effect of an orally-dosed caralluma fimbriata extract on appetite control and body composition in overweight adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c845db4a08d455284a50b69ae26cbcb
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The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults

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