Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brai...

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Autores principales:	Sebastian Hückesfeld, Philipp Schlegel, Anton Miroschnikow, Andreas Schoofs, Ingo Zinke, André N Haubrich, Casey M Schneider-Mizell, James W Truman, Richard D Fetter, Albert Cardona, Michael J Pankratz
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	neuroendocrine system connectome sensory synapses carbon dioxide interneuron neuropeptides Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9c88b8a123134ed3babb3375a0264da2
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spelling	oai:doaj.org-article:9c88b8a123134ed3babb3375a0264da22021-11-17T09:09:26ZUnveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila10.7554/eLife.657452050-084Xe65745https://doaj.org/article/9c88b8a123134ed3babb3375a0264da22021-06-01T00:00:00Zhttps://elifesciences.org/articles/65745https://doaj.org/toc/2050-084XNeuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brain are less well understood. Here, we use the transmission electron microscopy reconstruction of a whole central nervous system in the Drosophila larva to elucidate the sensory pathways and the interneurons that provide synaptic input to the neurosecretory cells projecting to the endocrine organs. Predicted by network modeling, we also identify a new carbon dioxide-responsive network that acts on a specific set of neurosecretory cells and that includes those expressing corazonin (Crz) and diuretic hormone 44 (Dh44) neuropeptides. Our analysis reveals a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways that converge onto distinct combinations of neuroendocrine outputs.Sebastian HückesfeldPhilipp SchlegelAnton MiroschnikowAndreas SchoofsIngo ZinkeAndré N HaubrichCasey M Schneider-MizellJames W TrumanRichard D FetterAlbert CardonaMichael J PankratzeLife Sciences Publications Ltdarticleneuroendocrine systemconnectomesensory synapsescarbon dioxideinterneuronneuropeptidesMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroendocrine system connectome sensory synapses carbon dioxide interneuron neuropeptides Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	neuroendocrine system connectome sensory synapses carbon dioxide interneuron neuropeptides Medicine R Science Q Biology (General) QH301-705.5 Sebastian Hückesfeld Philipp Schlegel Anton Miroschnikow Andreas Schoofs Ingo Zinke André N Haubrich Casey M Schneider-Mizell James W Truman Richard D Fetter Albert Cardona Michael J Pankratz Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila
description	Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brain are less well understood. Here, we use the transmission electron microscopy reconstruction of a whole central nervous system in the Drosophila larva to elucidate the sensory pathways and the interneurons that provide synaptic input to the neurosecretory cells projecting to the endocrine organs. Predicted by network modeling, we also identify a new carbon dioxide-responsive network that acts on a specific set of neurosecretory cells and that includes those expressing corazonin (Crz) and diuretic hormone 44 (Dh44) neuropeptides. Our analysis reveals a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways that converge onto distinct combinations of neuroendocrine outputs.
format	article
author	Sebastian Hückesfeld Philipp Schlegel Anton Miroschnikow Andreas Schoofs Ingo Zinke André N Haubrich Casey M Schneider-Mizell James W Truman Richard D Fetter Albert Cardona Michael J Pankratz
author_facet	Sebastian Hückesfeld Philipp Schlegel Anton Miroschnikow Andreas Schoofs Ingo Zinke André N Haubrich Casey M Schneider-Mizell James W Truman Richard D Fetter Albert Cardona Michael J Pankratz
author_sort	Sebastian Hückesfeld
title	Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila
title_short	Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila
title_full	Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila
title_fullStr	Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila
title_full_unstemmed	Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila
title_sort	unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in drosophila
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/9c88b8a123134ed3babb3375a0264da2
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Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

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