In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils

Narong Khuntikeo,1 Attapol Titapun,1 Nittaya Chamadol,2 Wuttisak Boonphongsathien,2 Prakasit Sa-Ngiamwibool,3 Simon D Taylor-Robinson,4 Christopher A Wadsworth,4 Shuo Zhang,5 Evdokia M Kardoulaki,6 Richard RA Syms6 1Department. of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002,...

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Autores principales:	Khuntikeo N, Titapun A, Chamadol N, Boonphongsathien W, Sa-Ngiamwibool P, Taylor-Robinson SD, Wadsworth CA, Zhang S, Kardoulaki EM, Syms RRA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cholangiocarcinoma t2 mapping catheter coil Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/9c8c2e454bc54dbf89101cd60c47a812
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spelling	oai:doaj.org-article:9c8c2e454bc54dbf89101cd60c47a8122021-12-02T11:14:38ZIn Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils1179-1535https://doaj.org/article/9c8c2e454bc54dbf89101cd60c47a8122020-07-01T00:00:00Zhttps://www.dovepress.com/in-vitro-intraductal-mri-and-t2-mapping-of-cholangiocarcinoma-using-ca-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Narong Khuntikeo,1 Attapol Titapun,1 Nittaya Chamadol,2 Wuttisak Boonphongsathien,2 Prakasit Sa-Ngiamwibool,3 Simon D Taylor-Robinson,4 Christopher A Wadsworth,4 Shuo Zhang,5 Evdokia M Kardoulaki,6 Richard RA Syms6 1Department. of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand; 2Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 3Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 4Division of Surgery and Cancer, Imperial College London, Paddington, London W2 1NY, UK; 5Philips Healthcare Germany, Health Systems, Clinical Science, Hamburg, Germany; 6EEE Department, Imperial College, London SW7 2AZ, UKCorrespondence: Simon D Taylor-RobinsonDivision of Surgery and Cancer, Imperial College London, Liver Unit, St. Mary’s Hospital, South Wharf Road, Paddington, London W2 1NY, UKTel +44 20 3312 6199Email s.taylor-robinson@imperial.ac.ukAim: Diagnostic imaging of early-stage cholangiocarcinoma is challenging. A previous in vitro study of fixed-tissue liver resection specimens investigated T2 mapping as a method of exploiting the locally increased signal-to-noise ratio (SNR) of duodenoscope coils for improved quantitative magnetic resonance imaging (MRI), despite their non-uniform sensitivity. This work applies similar methods to unfixed liver specimens using catheter-based receivers.Methods: Ex vivo intraductal MRI and T2 mapping were carried out at 3T on unfixed resection specimens obtained from cholangiocarcinoma patients immediately after surgery using a catheter coil based on a thin-film magneto-inductive waveguide, inserted directly into an intrahepatic duct.Results: Polypoid intraductal cholangiocarcinoma was imaged using fast spin-echo sequences. High-resolution T2 maps were extracted by fitting of data obtained at different echo times to mono-exponential models, and disease-induced changes were correlated with histopathology. An increase in T2 was found compared with fixed specimens and differences in T2 allowed the resolution of tumour tissue and malignant features such as polypoid morphology.Conclusion: Despite their limited field of view, useful data can be obtained using catheter coils, and T2 mapping offers an effective method of exploiting their local SNR advantage without the need for image correction.Keywords: Cholangiocarcinoma, T2 mapping, catheter coilKhuntikeo NTitapun AChamadol NBoonphongsathien WSa-Ngiamwibool PTaylor-Robinson SDWadsworth CAZhang SKardoulaki EMSyms RRADove Medical Pressarticlecholangiocarcinomat2 mappingcatheter coilDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 12, Pp 107-114 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholangiocarcinoma t2 mapping catheter coil Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	cholangiocarcinoma t2 mapping catheter coil Diseases of the digestive system. Gastroenterology RC799-869 Khuntikeo N Titapun A Chamadol N Boonphongsathien W Sa-Ngiamwibool P Taylor-Robinson SD Wadsworth CA Zhang S Kardoulaki EM Syms RRA In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils
description	Narong Khuntikeo,1 Attapol Titapun,1 Nittaya Chamadol,2 Wuttisak Boonphongsathien,2 Prakasit Sa-Ngiamwibool,3 Simon D Taylor-Robinson,4 Christopher A Wadsworth,4 Shuo Zhang,5 Evdokia M Kardoulaki,6 Richard RA Syms6 1Department. of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand; 2Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 3Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; 4Division of Surgery and Cancer, Imperial College London, Paddington, London W2 1NY, UK; 5Philips Healthcare Germany, Health Systems, Clinical Science, Hamburg, Germany; 6EEE Department, Imperial College, London SW7 2AZ, UKCorrespondence: Simon D Taylor-RobinsonDivision of Surgery and Cancer, Imperial College London, Liver Unit, St. Mary’s Hospital, South Wharf Road, Paddington, London W2 1NY, UKTel +44 20 3312 6199Email s.taylor-robinson@imperial.ac.ukAim: Diagnostic imaging of early-stage cholangiocarcinoma is challenging. A previous in vitro study of fixed-tissue liver resection specimens investigated T2 mapping as a method of exploiting the locally increased signal-to-noise ratio (SNR) of duodenoscope coils for improved quantitative magnetic resonance imaging (MRI), despite their non-uniform sensitivity. This work applies similar methods to unfixed liver specimens using catheter-based receivers.Methods: Ex vivo intraductal MRI and T2 mapping were carried out at 3T on unfixed resection specimens obtained from cholangiocarcinoma patients immediately after surgery using a catheter coil based on a thin-film magneto-inductive waveguide, inserted directly into an intrahepatic duct.Results: Polypoid intraductal cholangiocarcinoma was imaged using fast spin-echo sequences. High-resolution T2 maps were extracted by fitting of data obtained at different echo times to mono-exponential models, and disease-induced changes were correlated with histopathology. An increase in T2 was found compared with fixed specimens and differences in T2 allowed the resolution of tumour tissue and malignant features such as polypoid morphology.Conclusion: Despite their limited field of view, useful data can be obtained using catheter coils, and T2 mapping offers an effective method of exploiting their local SNR advantage without the need for image correction.Keywords: Cholangiocarcinoma, T2 mapping, catheter coil
format	article
author	Khuntikeo N Titapun A Chamadol N Boonphongsathien W Sa-Ngiamwibool P Taylor-Robinson SD Wadsworth CA Zhang S Kardoulaki EM Syms RRA
author_facet	Khuntikeo N Titapun A Chamadol N Boonphongsathien W Sa-Ngiamwibool P Taylor-Robinson SD Wadsworth CA Zhang S Kardoulaki EM Syms RRA
author_sort	Khuntikeo N
title	In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils
title_short	In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils
title_full	In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils
title_fullStr	In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils
title_full_unstemmed	In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils
title_sort	in vitro intraductal mri and t2 mapping of cholangiocarcinoma using catheter coils
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9c8c2e454bc54dbf89101cd60c47a812
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In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils

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