Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction

Injectable hydrogels have gained significant interest; yet, due to high viscosity, many are unsuitable for catheter delivery. Here, the authors report on cyclic peptides with low viscosity for catheter delivery, which form self-assembled peptide hydrogels following enzymatic cleavage and demonstrate...

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Autores principales:	Andrea S. Carlini, Roberto Gaetani, Rebecca L. Braden, Colin Luo, Karen L. Christman, Nathan C. Gianneschi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c8d2d6b278b4f31af17b734eaa8a3dd
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spelling	oai:doaj.org-article:9c8d2d6b278b4f31af17b734eaa8a3dd2021-12-02T14:39:18ZEnzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction10.1038/s41467-019-09587-y2041-1723https://doaj.org/article/9c8d2d6b278b4f31af17b734eaa8a3dd2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09587-yhttps://doaj.org/toc/2041-1723Injectable hydrogels have gained significant interest; yet, due to high viscosity, many are unsuitable for catheter delivery. Here, the authors report on cyclic peptides with low viscosity for catheter delivery, which form self-assembled peptide hydrogels following enzymatic cleavage and demonstrated delivery in vivo.Andrea S. CarliniRoberto GaetaniRebecca L. BradenColin LuoKaren L. ChristmanNathan C. GianneschiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea S. Carlini Roberto Gaetani Rebecca L. Braden Colin Luo Karen L. Christman Nathan C. Gianneschi Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
description	Injectable hydrogels have gained significant interest; yet, due to high viscosity, many are unsuitable for catheter delivery. Here, the authors report on cyclic peptides with low viscosity for catheter delivery, which form self-assembled peptide hydrogels following enzymatic cleavage and demonstrated delivery in vivo.
format	article
author	Andrea S. Carlini Roberto Gaetani Rebecca L. Braden Colin Luo Karen L. Christman Nathan C. Gianneschi
author_facet	Andrea S. Carlini Roberto Gaetani Rebecca L. Braden Colin Luo Karen L. Christman Nathan C. Gianneschi
author_sort	Andrea S. Carlini
title	Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
title_short	Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
title_full	Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
title_fullStr	Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
title_full_unstemmed	Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
title_sort	enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9c8d2d6b278b4f31af17b734eaa8a3dd
work_keys_str_mv	AT andreascarlini enzymeresponsiveprogelatorcyclicpeptidesforminimallyinvasivedeliverytotheheartpostmyocardialinfarction AT robertogaetani enzymeresponsiveprogelatorcyclicpeptidesforminimallyinvasivedeliverytotheheartpostmyocardialinfarction AT rebeccalbraden enzymeresponsiveprogelatorcyclicpeptidesforminimallyinvasivedeliverytotheheartpostmyocardialinfarction AT colinluo enzymeresponsiveprogelatorcyclicpeptidesforminimallyinvasivedeliverytotheheartpostmyocardialinfarction AT karenlchristman enzymeresponsiveprogelatorcyclicpeptidesforminimallyinvasivedeliverytotheheartpostmyocardialinfarction AT nathancgianneschi enzymeresponsiveprogelatorcyclicpeptidesforminimallyinvasivedeliverytotheheartpostmyocardialinfarction
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Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction

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