Engineering of Aerogel-Based Biomaterials for Biomedical Applications

Longpo Zheng,1,* Shaodi Zhang,1,* Zhengran Ying,1 Junjian Liu,1 Yinghong Zhou,2– 4 Feng Chen1,4 1Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 2The Institute of Health and...

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Autores principales:	Zheng L, Zhang S, Ying Z, Liu J, Zhou Y, Chen F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	aerogels wound healing bone regeneration drug delivery biomedical application Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9c8f94dc53824eeba749b8a2f3d88fbd
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spelling	oai:doaj.org-article:9c8f94dc53824eeba749b8a2f3d88fbd2021-12-02T10:13:44ZEngineering of Aerogel-Based Biomaterials for Biomedical Applications1178-2013https://doaj.org/article/9c8f94dc53824eeba749b8a2f3d88fbd2020-04-01T00:00:00Zhttps://www.dovepress.com/engineering-of-aerogel-based-biomaterials-for-biomedical-applications-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Longpo Zheng,1,* Shaodi Zhang,1,* Zhengran Ying,1 Junjian Liu,1 Yinghong Zhou,2– 4 Feng Chen1,4 1Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 2The Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia; 3Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510140, People’s Republic of China; 4The Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia*These authors contributed equally to this workCorrespondence: Feng Chen Email fchen@tongji.edu.cnAbstract: Biomaterials with porous structure and high surface area attract growing interest in biomedical research and applications. Aerogel-based biomaterials, as highly porous materials that are made from different sources of macromolecules, inorganic materials, and composites, mimic the structures of the biological extracellular matrix (ECM), which is a three-dimensional network of natural macromolecules (e.g., collagen and glycoproteins), and provide structural support and exert biochemical effects to surrounding cells in tissues. In recent years, the higher requirements on biomaterials significantly promote the design and development of aerogel-based biomaterials with high biocompatibility and biological activity. These biomaterials with multilevel hierarchical structures display excellent biological functions by promoting cell adhesion, proliferation, and differentiation, which are critical for biomedical applications. This review highlights and discusses the recent progress in the preparation of aerogel-based biomaterials and their biomedical applications, including wound healing, bone regeneration, and drug delivery. Moreover, the current review provides different strategies for modulating the biological performance of aerogel-based biomaterials and further sheds light on the current status of these materials in biomedical research.Keywords: aerogels, wound healing, bone regeneration, drug delivery, biomedical applicationZheng LZhang SYing ZLiu JZhou YChen FDove Medical Pressarticleaerogelswound healingbone regenerationdrug deliverybiomedical applicationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 2363-2378 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aerogels wound healing bone regeneration drug delivery biomedical application Medicine (General) R5-920
spellingShingle	aerogels wound healing bone regeneration drug delivery biomedical application Medicine (General) R5-920 Zheng L Zhang S Ying Z Liu J Zhou Y Chen F Engineering of Aerogel-Based Biomaterials for Biomedical Applications
description	Longpo Zheng,1,* Shaodi Zhang,1,* Zhengran Ying,1 Junjian Liu,1 Yinghong Zhou,2– 4 Feng Chen1,4 1Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 2The Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia; 3Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510140, People’s Republic of China; 4The Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia*These authors contributed equally to this workCorrespondence: Feng Chen Email fchen@tongji.edu.cnAbstract: Biomaterials with porous structure and high surface area attract growing interest in biomedical research and applications. Aerogel-based biomaterials, as highly porous materials that are made from different sources of macromolecules, inorganic materials, and composites, mimic the structures of the biological extracellular matrix (ECM), which is a three-dimensional network of natural macromolecules (e.g., collagen and glycoproteins), and provide structural support and exert biochemical effects to surrounding cells in tissues. In recent years, the higher requirements on biomaterials significantly promote the design and development of aerogel-based biomaterials with high biocompatibility and biological activity. These biomaterials with multilevel hierarchical structures display excellent biological functions by promoting cell adhesion, proliferation, and differentiation, which are critical for biomedical applications. This review highlights and discusses the recent progress in the preparation of aerogel-based biomaterials and their biomedical applications, including wound healing, bone regeneration, and drug delivery. Moreover, the current review provides different strategies for modulating the biological performance of aerogel-based biomaterials and further sheds light on the current status of these materials in biomedical research.Keywords: aerogels, wound healing, bone regeneration, drug delivery, biomedical application
format	article
author	Zheng L Zhang S Ying Z Liu J Zhou Y Chen F
author_facet	Zheng L Zhang S Ying Z Liu J Zhou Y Chen F
author_sort	Zheng L
title	Engineering of Aerogel-Based Biomaterials for Biomedical Applications
title_short	Engineering of Aerogel-Based Biomaterials for Biomedical Applications
title_full	Engineering of Aerogel-Based Biomaterials for Biomedical Applications
title_fullStr	Engineering of Aerogel-Based Biomaterials for Biomedical Applications
title_full_unstemmed	Engineering of Aerogel-Based Biomaterials for Biomedical Applications
title_sort	engineering of aerogel-based biomaterials for biomedical applications
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9c8f94dc53824eeba749b8a2f3d88fbd
work_keys_str_mv	AT zhengl engineeringofaerogelbasedbiomaterialsforbiomedicalapplications AT zhangs engineeringofaerogelbasedbiomaterialsforbiomedicalapplications AT yingz engineeringofaerogelbasedbiomaterialsforbiomedicalapplications AT liuj engineeringofaerogelbasedbiomaterialsforbiomedicalapplications AT zhouy engineeringofaerogelbasedbiomaterialsforbiomedicalapplications AT chenf engineeringofaerogelbasedbiomaterialsforbiomedicalapplications
_version_	1718397527392256000

Engineering of Aerogel-Based Biomaterials for Biomedical Applications

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