Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

Epigenetic reprogramming is a hallmark of cancer. Here the authors find that resetting primed human embryonic stem cells to naïve state results in the acquisition of a DNA methylation landscape that mirrors the cancer DNA methylome and provides evidence that the transition to naïve pluripotency and...

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Autores principales:	Hemalvi Patani, Michael D. Rushton, Jonathan Higham, Saul A. Teijeiro, David Oxley, Pedro Cutillas, Duncan Sproul, Gabriella Ficz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c90c9bfb585432585f2d24ff10bd5ed
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spelling	oai:doaj.org-article:9c90c9bfb585432585f2d24ff10bd5ed2021-12-02T16:26:40ZTransition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation10.1038/s41467-020-17269-32041-1723https://doaj.org/article/9c90c9bfb585432585f2d24ff10bd5ed2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17269-3https://doaj.org/toc/2041-1723Epigenetic reprogramming is a hallmark of cancer. Here the authors find that resetting primed human embryonic stem cells to naïve state results in the acquisition of a DNA methylation landscape that mirrors the cancer DNA methylome and provides evidence that the transition to naïve pluripotency and oncogenic transformation share common epigenetic trajectories.Hemalvi PataniMichael D. RushtonJonathan HighamSaul A. TeijeiroDavid OxleyPedro CutillasDuncan SproulGabriella FiczNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hemalvi Patani Michael D. Rushton Jonathan Higham Saul A. Teijeiro David Oxley Pedro Cutillas Duncan Sproul Gabriella Ficz Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
description	Epigenetic reprogramming is a hallmark of cancer. Here the authors find that resetting primed human embryonic stem cells to naïve state results in the acquisition of a DNA methylation landscape that mirrors the cancer DNA methylome and provides evidence that the transition to naïve pluripotency and oncogenic transformation share common epigenetic trajectories.
format	article
author	Hemalvi Patani Michael D. Rushton Jonathan Higham Saul A. Teijeiro David Oxley Pedro Cutillas Duncan Sproul Gabriella Ficz
author_facet	Hemalvi Patani Michael D. Rushton Jonathan Higham Saul A. Teijeiro David Oxley Pedro Cutillas Duncan Sproul Gabriella Ficz
author_sort	Hemalvi Patani
title	Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
title_short	Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
title_full	Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
title_fullStr	Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
title_full_unstemmed	Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation
title_sort	transition to naïve human pluripotency mirrors pan-cancer dna hypermethylation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9c90c9bfb585432585f2d24ff10bd5ed
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Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

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