Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A

Abstract Conventional therapeutic processes in patient with OSCC are associated with several unfavorable effects leading to patients with poor survival rate. Metformin has been shown to protect against a variety of specific diseases, including cancer. However, the precise roles and mechanisms underl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chang-Han Chen, Hsin-Ting Tsai, Hui-Ching Chuang, Li-Yen Shiu, Li-Jen Su, Tai-Jan Chiu, Sheng-Dean Luo, Fu-Min Fang, Chao-Cheng Huang, Chih-Yen Chien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c915cdee31944b1b3b57412bbfadf8d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c915cdee31944b1b3b57412bbfadf8d
record_format	dspace
spelling	oai:doaj.org-article:9c915cdee31944b1b3b57412bbfadf8d2021-12-02T15:05:59ZMetformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A10.1038/s41598-017-01353-82045-2322https://doaj.org/article/9c915cdee31944b1b3b57412bbfadf8d2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01353-8https://doaj.org/toc/2045-2322Abstract Conventional therapeutic processes in patient with OSCC are associated with several unfavorable effects leading to patients with poor survival rate. Metformin has been shown to protect against a variety of specific diseases, including cancer. However, the precise roles and mechanisms underlying the therapeutic effects of metformin on OSCC remain elusive. In the current study, in vitro and xenograft model experiments revealed that metformin inhibited growth and metastasis of oral cancer cells. Importantly, metformin-restrained tumorigenesis of oral cancer was accompanied with strong decrease of both Aurora-A and Late SV40 Factor (LSF) expressions. Furthermore, LSF contributed to Aurora-A-elicited malignancy behaviors of oral cancer via binding to the promoter region of Aurora-A. A significant correlation was observed between LSF and Aurora-A levels in a cohort of specimens of oral cancer. These findings showed that a novel LSF/Aurora-A-signaling inhibition supports the rationale of using metformin as potential OSCC therapeutics.Chang-Han ChenHsin-Ting TsaiHui-Ching ChuangLi-Yen ShiuLi-Jen SuTai-Jan ChiuSheng-Dean LuoFu-Min FangChao-Cheng HuangChih-Yen ChienNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chang-Han Chen Hsin-Ting Tsai Hui-Ching Chuang Li-Yen Shiu Li-Jen Su Tai-Jan Chiu Sheng-Dean Luo Fu-Min Fang Chao-Cheng Huang Chih-Yen Chien Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A
description	Abstract Conventional therapeutic processes in patient with OSCC are associated with several unfavorable effects leading to patients with poor survival rate. Metformin has been shown to protect against a variety of specific diseases, including cancer. However, the precise roles and mechanisms underlying the therapeutic effects of metformin on OSCC remain elusive. In the current study, in vitro and xenograft model experiments revealed that metformin inhibited growth and metastasis of oral cancer cells. Importantly, metformin-restrained tumorigenesis of oral cancer was accompanied with strong decrease of both Aurora-A and Late SV40 Factor (LSF) expressions. Furthermore, LSF contributed to Aurora-A-elicited malignancy behaviors of oral cancer via binding to the promoter region of Aurora-A. A significant correlation was observed between LSF and Aurora-A levels in a cohort of specimens of oral cancer. These findings showed that a novel LSF/Aurora-A-signaling inhibition supports the rationale of using metformin as potential OSCC therapeutics.
format	article
author	Chang-Han Chen Hsin-Ting Tsai Hui-Ching Chuang Li-Yen Shiu Li-Jen Su Tai-Jan Chiu Sheng-Dean Luo Fu-Min Fang Chao-Cheng Huang Chih-Yen Chien
author_facet	Chang-Han Chen Hsin-Ting Tsai Hui-Ching Chuang Li-Yen Shiu Li-Jen Su Tai-Jan Chiu Sheng-Dean Luo Fu-Min Fang Chao-Cheng Huang Chih-Yen Chien
author_sort	Chang-Han Chen
title	Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A
title_short	Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A
title_full	Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A
title_fullStr	Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A
title_full_unstemmed	Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A
title_sort	metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving late sv40 factor/aurora-a
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c915cdee31944b1b3b57412bbfadf8d
work_keys_str_mv	AT changhanchen metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT hsintingtsai metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT huichingchuang metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT liyenshiu metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT lijensu metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT taijanchiu metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT shengdeanluo metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT fuminfang metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT chaochenghuang metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa AT chihyenchien metformindisruptsmalignantbehavioroforalsquamouscellcarcinomaviaanovelsignalinginvolvinglatesv40factorauroraa
_version_	1718388660850655232

Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A

Ejemplares similares