A safety cap protects hydrogenase from oxygen attack

[FeFe]-hydrogenases catalyze the conversion of protons and electrons to molecular hydrogen, but upon exposure to oxygen, their catalytic cofactor is irreversibly inactivated. Here, the authors determine the crystal structure of hydrogenase CbA5H and identify a cysteine residue, which acts as a safet...

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Autores principales:	Martin Winkler, Jifu Duan, Andreas Rutz, Christina Felbek, Lisa Scholtysek, Oliver Lampret, Jan Jaenecke, Ulf-Peter Apfel, Gianfranco Gilardi, Francesca Valetti, Vincent Fourmond, Eckhard Hofmann, Christophe Léger, Thomas Happe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c9745d6547b4e9c8c0781318c4c1e61
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spelling	oai:doaj.org-article:9c9745d6547b4e9c8c0781318c4c1e612021-12-02T14:06:09ZA safety cap protects hydrogenase from oxygen attack10.1038/s41467-020-20861-22041-1723https://doaj.org/article/9c9745d6547b4e9c8c0781318c4c1e612021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20861-2https://doaj.org/toc/2041-1723[FeFe]-hydrogenases catalyze the conversion of protons and electrons to molecular hydrogen, but upon exposure to oxygen, their catalytic cofactor is irreversibly inactivated. Here, the authors determine the crystal structure of hydrogenase CbA5H and identify a cysteine residue, which acts as a safety cap that shields the active site from oxygen.Martin WinklerJifu DuanAndreas RutzChristina FelbekLisa ScholtysekOliver LampretJan JaeneckeUlf-Peter ApfelGianfranco GilardiFrancesca ValettiVincent FourmondEckhard HofmannChristophe LégerThomas HappeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Winkler Jifu Duan Andreas Rutz Christina Felbek Lisa Scholtysek Oliver Lampret Jan Jaenecke Ulf-Peter Apfel Gianfranco Gilardi Francesca Valetti Vincent Fourmond Eckhard Hofmann Christophe Léger Thomas Happe A safety cap protects hydrogenase from oxygen attack
description	[FeFe]-hydrogenases catalyze the conversion of protons and electrons to molecular hydrogen, but upon exposure to oxygen, their catalytic cofactor is irreversibly inactivated. Here, the authors determine the crystal structure of hydrogenase CbA5H and identify a cysteine residue, which acts as a safety cap that shields the active site from oxygen.
format	article
author	Martin Winkler Jifu Duan Andreas Rutz Christina Felbek Lisa Scholtysek Oliver Lampret Jan Jaenecke Ulf-Peter Apfel Gianfranco Gilardi Francesca Valetti Vincent Fourmond Eckhard Hofmann Christophe Léger Thomas Happe
author_facet	Martin Winkler Jifu Duan Andreas Rutz Christina Felbek Lisa Scholtysek Oliver Lampret Jan Jaenecke Ulf-Peter Apfel Gianfranco Gilardi Francesca Valetti Vincent Fourmond Eckhard Hofmann Christophe Léger Thomas Happe
author_sort	Martin Winkler
title	A safety cap protects hydrogenase from oxygen attack
title_short	A safety cap protects hydrogenase from oxygen attack
title_full	A safety cap protects hydrogenase from oxygen attack
title_fullStr	A safety cap protects hydrogenase from oxygen attack
title_full_unstemmed	A safety cap protects hydrogenase from oxygen attack
title_sort	safety cap protects hydrogenase from oxygen attack
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c9745d6547b4e9c8c0781318c4c1e61
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A safety cap protects hydrogenase from oxygen attack

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