Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles

The accurate and precise monitoring of epirubicin (EPR), one of the most widely used anticancer drugs, is significant for human and environmental health. In this context, we developed a highly sensitive electrochemical electrode for EPR detection based on nickel ferrite decorated with gold nanoparti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohammad Mehmandoust, Nevin Erk, Ceren Karaman, Fatemeh Karimi, Sadegh Salmanpour
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epirubicin anticancer monitoring nickel ferrite gold nanoparticles Mechanical engineering and machinery TJ1-1570
Acceso en línea:	https://doaj.org/article/9c98a80df83e4447a21986d104adb7e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c98a80df83e4447a21986d104adb7e6
record_format	dspace
spelling	oai:doaj.org-article:9c98a80df83e4447a21986d104adb7e62021-11-25T18:23:12ZSensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles10.3390/mi121113342072-666Xhttps://doaj.org/article/9c98a80df83e4447a21986d104adb7e62021-10-01T00:00:00Zhttps://www.mdpi.com/2072-666X/12/11/1334https://doaj.org/toc/2072-666XThe accurate and precise monitoring of epirubicin (EPR), one of the most widely used anticancer drugs, is significant for human and environmental health. In this context, we developed a highly sensitive electrochemical electrode for EPR detection based on nickel ferrite decorated with gold nanoparticles (Au@NiFe<sub>2</sub>O<sub>4</sub>) on the screen-printed electrode (SPE). Various spectral characteristic methods such as Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), energy-dispersive X-ray spectroscopy (EDX) and electrochemical impedance spectroscopy (EIS) were used to investigate the surface morphology and structure of the synthesized Au@NiFe<sub>2</sub>O<sub>4</sub> nanocomposite. The novel decorated electrode exhibited a high electrocatalytic activity toward the electrooxidation of EPR, and a nanomolar limit of detection (5.3 nM) was estimated using differential pulse voltammetry (DPV) with linear concentration ranges from 0.01 to 0.7 and 0.7 to 3.6 µM. The stability, selectivity, repeatability reproducibility and reusability, with a very low electrode response detection limit, make it very appropriate for determining trace amounts of EPR in pharmaceutical and clinical preparations.Mohammad MehmandoustNevin ErkCeren KaramanFatemeh KarimiSadegh SalmanpourMDPI AGarticleepirubicinanticancermonitoringnickel ferritegold nanoparticlesMechanical engineering and machineryTJ1-1570ENMicromachines, Vol 12, Iss 1334, p 1334 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epirubicin anticancer monitoring nickel ferrite gold nanoparticles Mechanical engineering and machinery TJ1-1570
spellingShingle	epirubicin anticancer monitoring nickel ferrite gold nanoparticles Mechanical engineering and machinery TJ1-1570 Mohammad Mehmandoust Nevin Erk Ceren Karaman Fatemeh Karimi Sadegh Salmanpour Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles
description	The accurate and precise monitoring of epirubicin (EPR), one of the most widely used anticancer drugs, is significant for human and environmental health. In this context, we developed a highly sensitive electrochemical electrode for EPR detection based on nickel ferrite decorated with gold nanoparticles (Au@NiFe<sub>2</sub>O<sub>4</sub>) on the screen-printed electrode (SPE). Various spectral characteristic methods such as Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), energy-dispersive X-ray spectroscopy (EDX) and electrochemical impedance spectroscopy (EIS) were used to investigate the surface morphology and structure of the synthesized Au@NiFe<sub>2</sub>O<sub>4</sub> nanocomposite. The novel decorated electrode exhibited a high electrocatalytic activity toward the electrooxidation of EPR, and a nanomolar limit of detection (5.3 nM) was estimated using differential pulse voltammetry (DPV) with linear concentration ranges from 0.01 to 0.7 and 0.7 to 3.6 µM. The stability, selectivity, repeatability reproducibility and reusability, with a very low electrode response detection limit, make it very appropriate for determining trace amounts of EPR in pharmaceutical and clinical preparations.
format	article
author	Mohammad Mehmandoust Nevin Erk Ceren Karaman Fatemeh Karimi Sadegh Salmanpour
author_facet	Mohammad Mehmandoust Nevin Erk Ceren Karaman Fatemeh Karimi Sadegh Salmanpour
author_sort	Mohammad Mehmandoust
title	Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles
title_short	Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles
title_full	Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles
title_fullStr	Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles
title_full_unstemmed	Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles
title_sort	sensitive and selective electrochemical detection of epirubicin as anticancer drug based on nickel ferrite decorated with gold nanoparticles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9c98a80df83e4447a21986d104adb7e6
work_keys_str_mv	AT mohammadmehmandoust sensitiveandselectiveelectrochemicaldetectionofepirubicinasanticancerdrugbasedonnickelferritedecoratedwithgoldnanoparticles AT nevinerk sensitiveandselectiveelectrochemicaldetectionofepirubicinasanticancerdrugbasedonnickelferritedecoratedwithgoldnanoparticles AT cerenkaraman sensitiveandselectiveelectrochemicaldetectionofepirubicinasanticancerdrugbasedonnickelferritedecoratedwithgoldnanoparticles AT fatemehkarimi sensitiveandselectiveelectrochemicaldetectionofepirubicinasanticancerdrugbasedonnickelferritedecoratedwithgoldnanoparticles AT sadeghsalmanpour sensitiveandselectiveelectrochemicaldetectionofepirubicinasanticancerdrugbasedonnickelferritedecoratedwithgoldnanoparticles
_version_	1718411274817110016

Sensitive and Selective Electrochemical Detection of Epirubicin as Anticancer Drug Based on Nickel Ferrite Decorated with Gold Nanoparticles

Ejemplares similares