Bacterial membrane vesicles as novel nanosystems for drug delivery

Sapna Jain, Jonathan Pillai Implants, Devices and Drug Delivery Systems Laboratory, Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Faridabad, Haryana, India Abstract: Bacterial membrane vesicles (BMVs) are closed spherical nanostructures that are shed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jain S, Pillai J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Bacteria membrane vesicles immune system vaccine bioengineering drug delivery. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9c9b9a7324bf42f6ae3bf5df6288a953
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c9b9a7324bf42f6ae3bf5df6288a953
record_format	dspace
spelling	oai:doaj.org-article:9c9b9a7324bf42f6ae3bf5df6288a9532021-12-02T02:42:19ZBacterial membrane vesicles as novel nanosystems for drug delivery1178-2013https://doaj.org/article/9c9b9a7324bf42f6ae3bf5df6288a9532017-08-01T00:00:00Zhttps://www.dovepress.com/bacterial-membrane-vesicles-as-novel-nanosystems-for-drug-delivery-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sapna Jain, Jonathan Pillai Implants, Devices and Drug Delivery Systems Laboratory, Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Faridabad, Haryana, India Abstract: Bacterial membrane vesicles (BMVs) are closed spherical nanostructures that are shed naturally and ubiquitously by most bacterial species both in vivo and in vitro. Researchers have elucidated their roles in long-distance transport of a wide array of cargoes, such as proteins, toxins, antigens, virulence factors, microbicidal agents and antibiotics. Given that these natural carriers are important players in intercellular communication, it has been hypothesized that they are equally well attuned for transport and delivery of exogenous therapeutic cargoes. Additionally, BMVs appear to possess specific properties that enable their utilization as drug delivery vehicles. These include their ability to evade the host immune system, protection of the therapeutic payload and natural stability. Using bioengineering approaches, BMVs have been applied as carriers of therapeutic moieties in vaccines and for targeted delivery in cancer. In this article, we explore BMVs from the perspective of understanding their applicability to drug delivery. BMV biology, including biogenesis, physiology and pathology, is briefly reviewed. Practical issues related to bioprocessing, loading of therapeutic moieties and characterization for enabling scalability and commercial viability are evaluated. Finally, challenges to clinical translation and rational design approaches for novel BMV formulations are presented. Although the realization of the full potential of BMVs in drug delivery hinges on the development of scalable approaches for their production as well as the refinement of targeting and loading methods, they are promising candidates for development of a novel generation of drug delivery vehicles in future. Keywords: bacteria, membrane vesicles, immune system, vaccine, bioengineering, drug delivery Jain SPillai JDove Medical PressarticleBacteriamembrane vesiclesimmune systemvaccinebioengineeringdrug delivery.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6329-6341 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bacteria membrane vesicles immune system vaccine bioengineering drug delivery. Medicine (General) R5-920
spellingShingle	Bacteria membrane vesicles immune system vaccine bioengineering drug delivery. Medicine (General) R5-920 Jain S Pillai J Bacterial membrane vesicles as novel nanosystems for drug delivery
description	Sapna Jain, Jonathan Pillai Implants, Devices and Drug Delivery Systems Laboratory, Centre for Biodesign and Diagnostics, Translational Health Science and Technology Institute, Faridabad, Haryana, India Abstract: Bacterial membrane vesicles (BMVs) are closed spherical nanostructures that are shed naturally and ubiquitously by most bacterial species both in vivo and in vitro. Researchers have elucidated their roles in long-distance transport of a wide array of cargoes, such as proteins, toxins, antigens, virulence factors, microbicidal agents and antibiotics. Given that these natural carriers are important players in intercellular communication, it has been hypothesized that they are equally well attuned for transport and delivery of exogenous therapeutic cargoes. Additionally, BMVs appear to possess specific properties that enable their utilization as drug delivery vehicles. These include their ability to evade the host immune system, protection of the therapeutic payload and natural stability. Using bioengineering approaches, BMVs have been applied as carriers of therapeutic moieties in vaccines and for targeted delivery in cancer. In this article, we explore BMVs from the perspective of understanding their applicability to drug delivery. BMV biology, including biogenesis, physiology and pathology, is briefly reviewed. Practical issues related to bioprocessing, loading of therapeutic moieties and characterization for enabling scalability and commercial viability are evaluated. Finally, challenges to clinical translation and rational design approaches for novel BMV formulations are presented. Although the realization of the full potential of BMVs in drug delivery hinges on the development of scalable approaches for their production as well as the refinement of targeting and loading methods, they are promising candidates for development of a novel generation of drug delivery vehicles in future. Keywords: bacteria, membrane vesicles, immune system, vaccine, bioengineering, drug delivery
format	article
author	Jain S Pillai J
author_facet	Jain S Pillai J
author_sort	Jain S
title	Bacterial membrane vesicles as novel nanosystems for drug delivery
title_short	Bacterial membrane vesicles as novel nanosystems for drug delivery
title_full	Bacterial membrane vesicles as novel nanosystems for drug delivery
title_fullStr	Bacterial membrane vesicles as novel nanosystems for drug delivery
title_full_unstemmed	Bacterial membrane vesicles as novel nanosystems for drug delivery
title_sort	bacterial membrane vesicles as novel nanosystems for drug delivery
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9c9b9a7324bf42f6ae3bf5df6288a953
work_keys_str_mv	AT jains bacterialmembranevesiclesasnovelnanosystemsfordrugdelivery AT pillaij bacterialmembranevesiclesasnovelnanosystemsfordrugdelivery
_version_	1718402238638981120

Bacterial membrane vesicles as novel nanosystems for drug delivery

Ejemplares similares