Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity in neurons and prime the TLR3-interferon pathway in...

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Autores principales:	Line S. Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vægter, Jens R. Nyengaard, Katherine A. Fitzgerald, Søren R. Paludan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c9ff79ecf304100a3671a4551b19557
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spelling	oai:doaj.org-article:9c9ff79ecf304100a3671a4551b195572021-12-02T17:32:21ZSensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS10.1038/ncomms133482041-1723https://doaj.org/article/9c9ff79ecf304100a3671a4551b195572016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13348https://doaj.org/toc/2041-1723The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity in neurons and prime the TLR3-interferon pathway in astrocytes.Line S. ReinertKatarína LopušnáHenriette WintherChenglong SunMartin K. ThomsenRamya NandakumarTrine H. MogensenMorten MeyerChristian VægterJens R. NyengaardKatherine A. FitzgeraldSøren R. PaludanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Line S. Reinert Katarína Lopušná Henriette Winther Chenglong Sun Martin K. Thomsen Ramya Nandakumar Trine H. Mogensen Morten Meyer Christian Vægter Jens R. Nyengaard Katherine A. Fitzgerald Søren R. Paludan Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
description	The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity in neurons and prime the TLR3-interferon pathway in astrocytes.
format	article
author	Line S. Reinert Katarína Lopušná Henriette Winther Chenglong Sun Martin K. Thomsen Ramya Nandakumar Trine H. Mogensen Morten Meyer Christian Vægter Jens R. Nyengaard Katherine A. Fitzgerald Søren R. Paludan
author_facet	Line S. Reinert Katarína Lopušná Henriette Winther Chenglong Sun Martin K. Thomsen Ramya Nandakumar Trine H. Mogensen Morten Meyer Christian Vægter Jens R. Nyengaard Katherine A. Fitzgerald Søren R. Paludan
author_sort	Line S. Reinert
title	Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
title_short	Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
title_full	Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
title_fullStr	Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
title_full_unstemmed	Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS
title_sort	sensing of hsv-1 by the cgas–sting pathway in microglia orchestrates antiviral defence in the cns
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9c9ff79ecf304100a3671a4551b19557
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Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

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