Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo

Tian-ju Wan,1 Yi-Chuan Yu,1 Xiao-gang Zhao,1 Ping Tang,1 Yong-shu Gong2 1Department of Emergency, Yongchuan Hospital of Chongqing Medical University, Chongqing, China; 2Department of Pediatrics, Yongchuan Hospital of Chongqing Medical University, Chongqing, China Background: Some patients still co...

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Autores principales:	Wan TJ, Yu YC, Zhao XG, Tang P, Gong YS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	residual dizziness benign paroxysmal positional vertigo BPPV cognitive behavior therapy CBT betahistine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9ca229b9482d4d77a7a496991cbb34ba
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spelling	oai:doaj.org-article:9ca229b9482d4d77a7a496991cbb34ba2021-12-02T04:23:33ZEfficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo1178-2021https://doaj.org/article/9ca229b9482d4d77a7a496991cbb34ba2018-11-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-betahistine-plus-cognitive-behavioral-therapy-on-residual--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tian-ju Wan,1 Yi-Chuan Yu,1 Xiao-gang Zhao,1 Ping Tang,1 Yong-shu Gong2 1Department of Emergency, Yongchuan Hospital of Chongqing Medical University, Chongqing, China; 2Department of Pediatrics, Yongchuan Hospital of Chongqing Medical University, Chongqing, China Background: Some patients still complain of residual dizziness after successful canalith repositioning procedure (CRP) for benign paroxysmal positional vertigo (BPPV). Previous study found that compared to the low-dose betahistine, the high-dose betahistine could yield better efficacy in treating residual dizziness. Therefore, this study was conducted to assess whether the addition of cognitive behavioral therapy (CBT) could make low-dose betahistine produce similar results to high-dose betahistine in treating residual dizziness. Methods: The recruited patients were randomly assigned to receive either low-dose betahistine (6 mg/time, three times/day) or high-dose betahistine (12 mg/time, three times/day). Patients in the low-dose group also received CBT (twice a week, 1 hour per time). The treatment was continued for 4 weeks. The duration of residual dizziness, 25-item Dizziness Handicap Inventory (DHI), Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS) were recorded and analyzed. The duration of residual dizziness and DHI score were the primary outcomes, and the HARS and HDRS scores were the secondary outcomes. Results: Each group had 50 patients. After treatment, the average DHI scores, HDRS scores, and HARS scores were significantly decreased in both groups. The duration of residual dizziness and average DHI score were nonsignificantly different (P=0.08; P=0.06) between the two groups, although they were lower in the low-dose group. Compared to the high-dose group, the low-dose group had the significantly lower average HDRS score (P=0.007) and HARS score (P=0.02). Meanwhile, four patients in the high-dose group experienced intolerable stomach upset. Conclusion: These results demonstrated that the addition of CBT could make low-dose betahistine produce similar results to high-dose betahistine in treating residual dizziness. Moreover, the low-dose betahistine plus CBT showed some advantages over high-dose betahistine in relieving depressive and anxiety symptoms and should be further explored. Keywords: residual dizziness, benign paroxysmal positional vertigo, BPPV, cognitive behavioral therapy, CBT, betahistineWan TJYu YCZhao XGTang PGong YSDove Medical Pressarticleresidual dizzinessbenign paroxysmal positional vertigoBPPVcognitive behavior therapyCBTbetahistineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2965-2971 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	residual dizziness benign paroxysmal positional vertigo BPPV cognitive behavior therapy CBT betahistine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	residual dizziness benign paroxysmal positional vertigo BPPV cognitive behavior therapy CBT betahistine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wan TJ Yu YC Zhao XG Tang P Gong YS Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
description	Tian-ju Wan,1 Yi-Chuan Yu,1 Xiao-gang Zhao,1 Ping Tang,1 Yong-shu Gong2 1Department of Emergency, Yongchuan Hospital of Chongqing Medical University, Chongqing, China; 2Department of Pediatrics, Yongchuan Hospital of Chongqing Medical University, Chongqing, China Background: Some patients still complain of residual dizziness after successful canalith repositioning procedure (CRP) for benign paroxysmal positional vertigo (BPPV). Previous study found that compared to the low-dose betahistine, the high-dose betahistine could yield better efficacy in treating residual dizziness. Therefore, this study was conducted to assess whether the addition of cognitive behavioral therapy (CBT) could make low-dose betahistine produce similar results to high-dose betahistine in treating residual dizziness. Methods: The recruited patients were randomly assigned to receive either low-dose betahistine (6 mg/time, three times/day) or high-dose betahistine (12 mg/time, three times/day). Patients in the low-dose group also received CBT (twice a week, 1 hour per time). The treatment was continued for 4 weeks. The duration of residual dizziness, 25-item Dizziness Handicap Inventory (DHI), Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS) were recorded and analyzed. The duration of residual dizziness and DHI score were the primary outcomes, and the HARS and HDRS scores were the secondary outcomes. Results: Each group had 50 patients. After treatment, the average DHI scores, HDRS scores, and HARS scores were significantly decreased in both groups. The duration of residual dizziness and average DHI score were nonsignificantly different (P=0.08; P=0.06) between the two groups, although they were lower in the low-dose group. Compared to the high-dose group, the low-dose group had the significantly lower average HDRS score (P=0.007) and HARS score (P=0.02). Meanwhile, four patients in the high-dose group experienced intolerable stomach upset. Conclusion: These results demonstrated that the addition of CBT could make low-dose betahistine produce similar results to high-dose betahistine in treating residual dizziness. Moreover, the low-dose betahistine plus CBT showed some advantages over high-dose betahistine in relieving depressive and anxiety symptoms and should be further explored. Keywords: residual dizziness, benign paroxysmal positional vertigo, BPPV, cognitive behavioral therapy, CBT, betahistine
format	article
author	Wan TJ Yu YC Zhao XG Tang P Gong YS
author_facet	Wan TJ Yu YC Zhao XG Tang P Gong YS
author_sort	Wan TJ
title	Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
title_short	Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
title_full	Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
title_fullStr	Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
title_full_unstemmed	Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
title_sort	efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9ca229b9482d4d77a7a496991cbb34ba
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_version_	1718401263614296064

Efficacy of betahistine plus cognitive behavioral therapy on residual dizziness after successful canalith repositioning procedure for benign paroxysmal positional vertigo

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