Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

The tick-borne encephalitis virus (TBEV) causes thousands of cases of meningitis and encephalitis annually. Here, the authors describe a cryo-EM structure of the TBEV virion bound by Fab fragments of the neutralizing antibody 19/1786, revealing a mechanism whereby this antibody prevents virus membra...

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Autores principales:	Tibor Füzik, Petra Formanová, Daniel Růžek, Kentaro Yoshii, Matthias Niedrig, Pavel Plevka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ca299bbfe594c17985845abd4f92848
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spelling	oai:doaj.org-article:9ca299bbfe594c17985845abd4f928482021-12-02T17:31:26ZStructure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody10.1038/s41467-018-02882-02041-1723https://doaj.org/article/9ca299bbfe594c17985845abd4f928482018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02882-0https://doaj.org/toc/2041-1723The tick-borne encephalitis virus (TBEV) causes thousands of cases of meningitis and encephalitis annually. Here, the authors describe a cryo-EM structure of the TBEV virion bound by Fab fragments of the neutralizing antibody 19/1786, revealing a mechanism whereby this antibody prevents virus membrane fusion.Tibor FüzikPetra FormanováDaniel RůžekKentaro YoshiiMatthias NiedrigPavel PlevkaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tibor Füzik Petra Formanová Daniel Růžek Kentaro Yoshii Matthias Niedrig Pavel Plevka Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
description	The tick-borne encephalitis virus (TBEV) causes thousands of cases of meningitis and encephalitis annually. Here, the authors describe a cryo-EM structure of the TBEV virion bound by Fab fragments of the neutralizing antibody 19/1786, revealing a mechanism whereby this antibody prevents virus membrane fusion.
format	article
author	Tibor Füzik Petra Formanová Daniel Růžek Kentaro Yoshii Matthias Niedrig Pavel Plevka
author_facet	Tibor Füzik Petra Formanová Daniel Růžek Kentaro Yoshii Matthias Niedrig Pavel Plevka
author_sort	Tibor Füzik
title	Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
title_short	Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
title_full	Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
title_fullStr	Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
title_full_unstemmed	Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
title_sort	structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9ca299bbfe594c17985845abd4f92848
work_keys_str_mv	AT tiborfuzik structureoftickborneencephalitisvirusanditsneutralizationbyamonoclonalantibody AT petraformanova structureoftickborneencephalitisvirusanditsneutralizationbyamonoclonalantibody AT danielruzek structureoftickborneencephalitisvirusanditsneutralizationbyamonoclonalantibody AT kentaroyoshii structureoftickborneencephalitisvirusanditsneutralizationbyamonoclonalantibody AT matthiasniedrig structureoftickborneencephalitisvirusanditsneutralizationbyamonoclonalantibody AT pavelplevka structureoftickborneencephalitisvirusanditsneutralizationbyamonoclonalantibody
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Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody

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