The role of recombination for the coevolutionary dynamics of HIV and the immune response.

The evolutionary implications of recombination in HIV remain not fully understood. A plausible effect could be an enhancement of immune escape from cytotoxic T lymphocytes (CTLs). In order to test this hypothesis, we constructed a population dynamic model of immune escape in HIV and examined the vir...

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Autores principales:	Rafal Mostowy, Roger D Kouyos, David Fouchet, Sebastian Bonhoeffer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ca4f163585048dfa8421a0cb80bfed6
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spelling	oai:doaj.org-article:9ca4f163585048dfa8421a0cb80bfed62021-11-18T06:58:34ZThe role of recombination for the coevolutionary dynamics of HIV and the immune response.1932-620310.1371/journal.pone.0016052https://doaj.org/article/9ca4f163585048dfa8421a0cb80bfed62011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364750/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The evolutionary implications of recombination in HIV remain not fully understood. A plausible effect could be an enhancement of immune escape from cytotoxic T lymphocytes (CTLs). In order to test this hypothesis, we constructed a population dynamic model of immune escape in HIV and examined the viral-immune dynamics with and without recombination. Our model shows that recombination (i) increases the genetic diversity of the viral population, (ii) accelerates the emergence of escape mutations with and without compensatory mutations, and (iii) accelerates the acquisition of immune escape mutations in the early stage of viral infection. We see a particularly strong impact of recombination in systems with broad, non-immunodominant CTL responses. Overall, our study argues for the importance of recombination in HIV in allowing the virus to adapt to changing selective pressures as imposed by the immune system and shows that the effect of recombination depends on the immunodominance pattern of effector T cell responses.Rafal MostowyRoger D KouyosDavid FouchetSebastian BonhoefferPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e16052 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rafal Mostowy Roger D Kouyos David Fouchet Sebastian Bonhoeffer The role of recombination for the coevolutionary dynamics of HIV and the immune response.
description	The evolutionary implications of recombination in HIV remain not fully understood. A plausible effect could be an enhancement of immune escape from cytotoxic T lymphocytes (CTLs). In order to test this hypothesis, we constructed a population dynamic model of immune escape in HIV and examined the viral-immune dynamics with and without recombination. Our model shows that recombination (i) increases the genetic diversity of the viral population, (ii) accelerates the emergence of escape mutations with and without compensatory mutations, and (iii) accelerates the acquisition of immune escape mutations in the early stage of viral infection. We see a particularly strong impact of recombination in systems with broad, non-immunodominant CTL responses. Overall, our study argues for the importance of recombination in HIV in allowing the virus to adapt to changing selective pressures as imposed by the immune system and shows that the effect of recombination depends on the immunodominance pattern of effector T cell responses.
format	article
author	Rafal Mostowy Roger D Kouyos David Fouchet Sebastian Bonhoeffer
author_facet	Rafal Mostowy Roger D Kouyos David Fouchet Sebastian Bonhoeffer
author_sort	Rafal Mostowy
title	The role of recombination for the coevolutionary dynamics of HIV and the immune response.
title_short	The role of recombination for the coevolutionary dynamics of HIV and the immune response.
title_full	The role of recombination for the coevolutionary dynamics of HIV and the immune response.
title_fullStr	The role of recombination for the coevolutionary dynamics of HIV and the immune response.
title_full_unstemmed	The role of recombination for the coevolutionary dynamics of HIV and the immune response.
title_sort	role of recombination for the coevolutionary dynamics of hiv and the immune response.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9ca4f163585048dfa8421a0cb80bfed6
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The role of recombination for the coevolutionary dynamics of HIV and the immune response.

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