Increased Fat Taste Preference in Progranulin-Deficient Mice
Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary fats. Progranulin-deficient mice (Grn<sup>−/...
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2021
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oai:doaj.org-article:9ca860e21d8f404cb6a2e893e6c608c82021-11-25T18:36:57ZIncreased Fat Taste Preference in Progranulin-Deficient Mice10.3390/nu131141252072-6643https://doaj.org/article/9ca860e21d8f404cb6a2e893e6c608c82021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4125https://doaj.org/toc/2072-6643Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary fats. Progranulin-deficient mice (Grn<sup>−/−</sup>) are moderately overweight during middle age. We therefore asked if there was a connection between progranulin/CD36 in the tongue and fat taste preferences. By using unbiased behavioral analyses in IntelliCages and Phenomaster cages we showed that progranulin-deficient mice (Grn<sup>−/−</sup>) developed a strong preference of fat taste in the form of 2% milk over 0.3% milk, and for diluted MCTs versus tap water. The fat preference in the 7d-IntelliCage observation period caused an increase of 10% in the body weight of Grn<sup>−/−</sup> mice, which did not occur in the wildtype controls. CD36 expression in taste buds was reduced in Grn<sup>−/−</sup> mice at RNA and histology levels. There were no differences in the plasma or tongue lipids of various classes including sphingolipids, ceramides and endocannabinoids. The data suggest that progranulin deficiency leads to a lower expression of CD36 in the tongue resulting in a stronger urge for fatty taste and fatty nutrition.Lana SchumannAnnett Wilken-SchmitzSandra TrautmannAlexandra VogelYannick SchreiberLisa HahnefeldRobert GurkeGerd GeisslingerIrmgard TegederMDPI AGarticletaste budslipidsprogranulinCD36IntelliCageNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4125, p 4125 (2021) |
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| topic |
taste buds lipids progranulin CD36 IntelliCage Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
taste buds lipids progranulin CD36 IntelliCage Nutrition. Foods and food supply TX341-641 Lana Schumann Annett Wilken-Schmitz Sandra Trautmann Alexandra Vogel Yannick Schreiber Lisa Hahnefeld Robert Gurke Gerd Geisslinger Irmgard Tegeder Increased Fat Taste Preference in Progranulin-Deficient Mice |
| description |
Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary fats. Progranulin-deficient mice (Grn<sup>−/−</sup>) are moderately overweight during middle age. We therefore asked if there was a connection between progranulin/CD36 in the tongue and fat taste preferences. By using unbiased behavioral analyses in IntelliCages and Phenomaster cages we showed that progranulin-deficient mice (Grn<sup>−/−</sup>) developed a strong preference of fat taste in the form of 2% milk over 0.3% milk, and for diluted MCTs versus tap water. The fat preference in the 7d-IntelliCage observation period caused an increase of 10% in the body weight of Grn<sup>−/−</sup> mice, which did not occur in the wildtype controls. CD36 expression in taste buds was reduced in Grn<sup>−/−</sup> mice at RNA and histology levels. There were no differences in the plasma or tongue lipids of various classes including sphingolipids, ceramides and endocannabinoids. The data suggest that progranulin deficiency leads to a lower expression of CD36 in the tongue resulting in a stronger urge for fatty taste and fatty nutrition. |
| format |
article |
| author |
Lana Schumann Annett Wilken-Schmitz Sandra Trautmann Alexandra Vogel Yannick Schreiber Lisa Hahnefeld Robert Gurke Gerd Geisslinger Irmgard Tegeder |
| author_facet |
Lana Schumann Annett Wilken-Schmitz Sandra Trautmann Alexandra Vogel Yannick Schreiber Lisa Hahnefeld Robert Gurke Gerd Geisslinger Irmgard Tegeder |
| author_sort |
Lana Schumann |
| title |
Increased Fat Taste Preference in Progranulin-Deficient Mice |
| title_short |
Increased Fat Taste Preference in Progranulin-Deficient Mice |
| title_full |
Increased Fat Taste Preference in Progranulin-Deficient Mice |
| title_fullStr |
Increased Fat Taste Preference in Progranulin-Deficient Mice |
| title_full_unstemmed |
Increased Fat Taste Preference in Progranulin-Deficient Mice |
| title_sort |
increased fat taste preference in progranulin-deficient mice |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/9ca860e21d8f404cb6a2e893e6c608c8 |
| work_keys_str_mv |
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