Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis

Amir Mohsenin,1 John Sinard,1,2 John J Huang11Department of Ophthalmology and Visual Science, 2Department of Pathology, Yale University School of Medicine, New Haven, CT, USAAbstract: This report describes a unique case of coexisting necrobiotic xanthogranuloma and chronic lymphocytic leukemia in a...

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Autores principales:	Mohsenin A, Sinard J, Huang JJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9cb17ee1b9e44069b59df91cea43727c
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spelling	oai:doaj.org-article:9cb17ee1b9e44069b59df91cea43727c2021-12-02T00:11:04ZNecrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis1177-54671177-5483https://doaj.org/article/9cb17ee1b9e44069b59df91cea43727c2012-12-01T00:00:00Zhttp://www.dovepress.com/necrobiotic-xanthogranuloma-and-chronic-lymphocytic-leukemia-of-the-co-a11746https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Amir Mohsenin,1 John Sinard,1,2 John J Huang11Department of Ophthalmology and Visual Science, 2Department of Pathology, Yale University School of Medicine, New Haven, CT, USAAbstract: This report describes a unique case of coexisting necrobiotic xanthogranuloma and chronic lymphocytic leukemia in a patient presenting with scleritis and uveitis. A 53-year-old Caucasian man diagnosed with anterior uveitis and scleritis for the prior year was referred to our uveitis clinic for further evaluation. Prior uveitis/scleritis workup performed by the referring ophthalmologist was negative. Examination demonstrated unilateral uveitis and posterior scleritis along with bilateral conjunctival lesions. Incisional biopsy of the conjunctiva was carried out. The excised tissue was sent fresh for histopathologic studies. Slit-lamp examination revealed bilateral yellow-white bulbar conjunctival lesions, 1+ conjunctival injection OU, stellate keratic precipitates OS with 25 cells per high-powered field. Funduscopic examination was significant for subretinal fluid OS. Conjunctival biopsy revealed necrobiotic xanthogranuloma and chronic lymphocytic leukemia. Systemic workup demonstrated paraproteinemia consistent with necrobiotic xanthogranuloma and a complete blood count consistent with leukemia. This case demonstrates an atypical presentation of necrobiotic xanthogranuloma and concomitant chronic lymphocytic leukemia presenting in the form of uveitis, scleritis, and conjunctival infiltration. Masquerade syndromes, such as necrobiotic xanthogranuloma and leukemia, must be kept in mind when treating patients with uveitis or scleritis with negative workups.Keywords: necrobiotic xanthogranuloma, chronic lymphocytic leukemia, uveitis, scleritis, masquerade syndromeMohsenin ASinard JHuang JJDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 2045-2047 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mohsenin A Sinard J Huang JJ Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
description	Amir Mohsenin,1 John Sinard,1,2 John J Huang11Department of Ophthalmology and Visual Science, 2Department of Pathology, Yale University School of Medicine, New Haven, CT, USAAbstract: This report describes a unique case of coexisting necrobiotic xanthogranuloma and chronic lymphocytic leukemia in a patient presenting with scleritis and uveitis. A 53-year-old Caucasian man diagnosed with anterior uveitis and scleritis for the prior year was referred to our uveitis clinic for further evaluation. Prior uveitis/scleritis workup performed by the referring ophthalmologist was negative. Examination demonstrated unilateral uveitis and posterior scleritis along with bilateral conjunctival lesions. Incisional biopsy of the conjunctiva was carried out. The excised tissue was sent fresh for histopathologic studies. Slit-lamp examination revealed bilateral yellow-white bulbar conjunctival lesions, 1+ conjunctival injection OU, stellate keratic precipitates OS with 25 cells per high-powered field. Funduscopic examination was significant for subretinal fluid OS. Conjunctival biopsy revealed necrobiotic xanthogranuloma and chronic lymphocytic leukemia. Systemic workup demonstrated paraproteinemia consistent with necrobiotic xanthogranuloma and a complete blood count consistent with leukemia. This case demonstrates an atypical presentation of necrobiotic xanthogranuloma and concomitant chronic lymphocytic leukemia presenting in the form of uveitis, scleritis, and conjunctival infiltration. Masquerade syndromes, such as necrobiotic xanthogranuloma and leukemia, must be kept in mind when treating patients with uveitis or scleritis with negative workups.Keywords: necrobiotic xanthogranuloma, chronic lymphocytic leukemia, uveitis, scleritis, masquerade syndrome
format	article
author	Mohsenin A Sinard J Huang JJ
author_facet	Mohsenin A Sinard J Huang JJ
author_sort	Mohsenin A
title	Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
title_short	Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
title_full	Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
title_fullStr	Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
title_full_unstemmed	Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
title_sort	necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9cb17ee1b9e44069b59df91cea43727c
work_keys_str_mv	AT mohsenina necrobioticxanthogranulomaandchroniclymphocyticleukemiaoftheconjunctivamasqueradingasscleritisanduveitis AT sinardj necrobioticxanthogranulomaandchroniclymphocyticleukemiaoftheconjunctivamasqueradingasscleritisanduveitis AT huangjj necrobioticxanthogranulomaandchroniclymphocyticleukemiaoftheconjunctivamasqueradingasscleritisanduveitis
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Necrobiotic xanthogranuloma and chronic lymphocytic leukemia of the conjunctiva masquerading as scleritis and uveitis

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