One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery

Abstract Background Photoresponsive drug delivery can achieve spatiotemporal control of drug accumulation at desired sites. Long-wavelength light is preferable owing to its deep tissue penetration and low toxicity. One-photon upconversion-like photolysis via triplet–triplet energy transfer (TTET) be...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaiqi Long, Han Han, Weirong Kang, Wen Lv, Lang Wang, Yufeng Wang, Liang Ge, Weiping Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Photoresponsive drug delivery Self-assembly One-photon upconversion-like photolysis Cancer therapy Three-legged molecules Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/9cb37ae1d4ba4b44be0e0a73dc318587
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9cb37ae1d4ba4b44be0e0a73dc318587
record_format	dspace
spelling	oai:doaj.org-article:9cb37ae1d4ba4b44be0e0a73dc3185872021-11-08T11:01:24ZOne-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery10.1186/s12951-021-01103-z1477-3155https://doaj.org/article/9cb37ae1d4ba4b44be0e0a73dc3185872021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01103-zhttps://doaj.org/toc/1477-3155Abstract Background Photoresponsive drug delivery can achieve spatiotemporal control of drug accumulation at desired sites. Long-wavelength light is preferable owing to its deep tissue penetration and low toxicity. One-photon upconversion-like photolysis via triplet–triplet energy transfer (TTET) between photosensitizer and photoresponsive group enables the use of long-wavelength light to activate short-wavelength light-responsive groups. However, such process requires oxygen-free environment to achieve efficient photolysis due to the oxygen quenching of triplet excited states. Results Herein, we report a strategy that uses red light to trigger disassembly of small-molecule nanoparticles by one-photon upconversion-like photolysis for cancer therapy. A photocleavable trigonal molecule, BTAEA, self-assembled into nanoparticles and enclosed photosensitizer, PtTPBP. Such nanoparticles protected TTET-based photolysis from oxygen quenching in normoxia aqueous solutions, resulting in efficient red light-triggered BTAEA cleavage, dissociation of nanoparticles and subsequent cargo release. With paclitaxel as the model drug, the red light-triggered drug release system demonstrated promising anti-tumor efficacy both in vitro and in vivo. Conclusions This study provides a practical reference for constructing photoresponsive nanocarriers based on the one-photon upconversion-like photolysis. Graphical AbstractKaiqi LongHan HanWeirong KangWen LvLang WangYufeng WangLiang GeWeiping WangBMCarticlePhotoresponsive drug deliverySelf-assemblyOne-photon upconversion-like photolysisCancer therapyThree-legged moleculesBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Photoresponsive drug delivery Self-assembly One-photon upconversion-like photolysis Cancer therapy Three-legged molecules Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Photoresponsive drug delivery Self-assembly One-photon upconversion-like photolysis Cancer therapy Three-legged molecules Biotechnology TP248.13-248.65 Medical technology R855-855.5 Kaiqi Long Han Han Weirong Kang Wen Lv Lang Wang Yufeng Wang Liang Ge Weiping Wang One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
description	Abstract Background Photoresponsive drug delivery can achieve spatiotemporal control of drug accumulation at desired sites. Long-wavelength light is preferable owing to its deep tissue penetration and low toxicity. One-photon upconversion-like photolysis via triplet–triplet energy transfer (TTET) between photosensitizer and photoresponsive group enables the use of long-wavelength light to activate short-wavelength light-responsive groups. However, such process requires oxygen-free environment to achieve efficient photolysis due to the oxygen quenching of triplet excited states. Results Herein, we report a strategy that uses red light to trigger disassembly of small-molecule nanoparticles by one-photon upconversion-like photolysis for cancer therapy. A photocleavable trigonal molecule, BTAEA, self-assembled into nanoparticles and enclosed photosensitizer, PtTPBP. Such nanoparticles protected TTET-based photolysis from oxygen quenching in normoxia aqueous solutions, resulting in efficient red light-triggered BTAEA cleavage, dissociation of nanoparticles and subsequent cargo release. With paclitaxel as the model drug, the red light-triggered drug release system demonstrated promising anti-tumor efficacy both in vitro and in vivo. Conclusions This study provides a practical reference for constructing photoresponsive nanocarriers based on the one-photon upconversion-like photolysis. Graphical Abstract
format	article
author	Kaiqi Long Han Han Weirong Kang Wen Lv Lang Wang Yufeng Wang Liang Ge Weiping Wang
author_facet	Kaiqi Long Han Han Weirong Kang Wen Lv Lang Wang Yufeng Wang Liang Ge Weiping Wang
author_sort	Kaiqi Long
title	One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
title_short	One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
title_full	One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
title_fullStr	One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
title_full_unstemmed	One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
title_sort	one-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9cb37ae1d4ba4b44be0e0a73dc318587
work_keys_str_mv	AT kaiqilong onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT hanhan onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT weirongkang onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT wenlv onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT langwang onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT yufengwang onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT liangge onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery AT weipingwang onephotonredlighttriggereddisassemblyofsmallmoleculenanoparticlesfordrugdelivery
_version_	1718442452118929408

One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery

Ejemplares similares