Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population

Globally, Autism spectrum disorder (ASD) has been rapidly increasing in the past decades, and still the aetiological factors that contribute to ASD remains unclear. Since a wide plethora of factors can be involved in the development of ASD, we aimed to investigate various paternal, prenatal, perinat...

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Autores principales:	Vellingiri Balachandar, Geetha Bharathi, Kaavya Jayaramayya, Anila Venugopal, Iyer Mahalaxmi, Arul Narayanasamy, Avanthika Bharathi, Abilash Valsala Gopalakrishnan, Nachimuthu Senthil Kumar, Mohana Devi Subramaniam
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Autism spectrum disorder (ASD) Neurodevelopmental disorder Aetiology Risk factors Parental influenceisk factors, Parental influence Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9cb54dcdfade4229b6c5fbbabb471a1c
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spelling	oai:doaj.org-article:9cb54dcdfade4229b6c5fbbabb471a1c2021-11-14T04:35:47ZAutism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population2666-459310.1016/j.dscb.2021.100024https://doaj.org/article/9cb54dcdfade4229b6c5fbbabb471a1c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666459321000238https://doaj.org/toc/2666-4593Globally, Autism spectrum disorder (ASD) has been rapidly increasing in the past decades, and still the aetiological factors that contribute to ASD remains unclear. Since a wide plethora of factors can be involved in the development of ASD, we aimed to investigate various paternal, prenatal, perinatal, neonatal and environmental risk factors using broad and reliable classification methods. The targeted population were children (between 3 -18 years) residing in Tamil Nadu, India and were identified as children with ASD (n = 346) on the basis of DSM-V and CARS. Each child was matched by gender and age (±2) to 1038 controls (735 males, 303 females) in a case-control design in the ratio 1:3. Questionnaires and other medical records of participants and controls were surveyed according to the study criteria. The prenatal risk factors that were significant for children with ASD were advanced parental age, parental smoking and passive smoking, stress and environmental exposures during pregnancy. The significant neonatal factors were hypoxia and birth-weight. Hypoxia was a significant neonatal factor that was different among ASD children and controls and birth weight emerged as a prominent factor associated with autism severity. Additional investigations focused on both genetic and environmental factors that link these ASD risk factors individually or collectively are needed. Hence, an accurate understanding of etiology can help in comprehending the intricacies of this multifaceted condition and may pave way for early diagnosis, prevention and treatment of ASD.Vellingiri BalachandarGeetha BharathiKaavya JayaramayyaAnila VenugopalIyer MahalaxmiArul NarayanasamyAvanthika BharathiAbilash Valsala GopalakrishnanNachimuthu Senthil KumarMohana Devi SubramaniamElsevierarticleAutism spectrum disorder (ASD)Neurodevelopmental disorderAetiologyRisk factorsParental influenceisk factors, Parental influenceNeurology. Diseases of the nervous systemRC346-429ENBrain Disorders, Vol 4, Iss , Pp 100024- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autism spectrum disorder (ASD) Neurodevelopmental disorder Aetiology Risk factors Parental influenceisk factors, Parental influence Neurology. Diseases of the nervous system RC346-429
spellingShingle	Autism spectrum disorder (ASD) Neurodevelopmental disorder Aetiology Risk factors Parental influenceisk factors, Parental influence Neurology. Diseases of the nervous system RC346-429 Vellingiri Balachandar Geetha Bharathi Kaavya Jayaramayya Anila Venugopal Iyer Mahalaxmi Arul Narayanasamy Avanthika Bharathi Abilash Valsala Gopalakrishnan Nachimuthu Senthil Kumar Mohana Devi Subramaniam Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population
description	Globally, Autism spectrum disorder (ASD) has been rapidly increasing in the past decades, and still the aetiological factors that contribute to ASD remains unclear. Since a wide plethora of factors can be involved in the development of ASD, we aimed to investigate various paternal, prenatal, perinatal, neonatal and environmental risk factors using broad and reliable classification methods. The targeted population were children (between 3 -18 years) residing in Tamil Nadu, India and were identified as children with ASD (n = 346) on the basis of DSM-V and CARS. Each child was matched by gender and age (±2) to 1038 controls (735 males, 303 females) in a case-control design in the ratio 1:3. Questionnaires and other medical records of participants and controls were surveyed according to the study criteria. The prenatal risk factors that were significant for children with ASD were advanced parental age, parental smoking and passive smoking, stress and environmental exposures during pregnancy. The significant neonatal factors were hypoxia and birth-weight. Hypoxia was a significant neonatal factor that was different among ASD children and controls and birth weight emerged as a prominent factor associated with autism severity. Additional investigations focused on both genetic and environmental factors that link these ASD risk factors individually or collectively are needed. Hence, an accurate understanding of etiology can help in comprehending the intricacies of this multifaceted condition and may pave way for early diagnosis, prevention and treatment of ASD.
format	article
author	Vellingiri Balachandar Geetha Bharathi Kaavya Jayaramayya Anila Venugopal Iyer Mahalaxmi Arul Narayanasamy Avanthika Bharathi Abilash Valsala Gopalakrishnan Nachimuthu Senthil Kumar Mohana Devi Subramaniam
author_facet	Vellingiri Balachandar Geetha Bharathi Kaavya Jayaramayya Anila Venugopal Iyer Mahalaxmi Arul Narayanasamy Avanthika Bharathi Abilash Valsala Gopalakrishnan Nachimuthu Senthil Kumar Mohana Devi Subramaniam
author_sort	Vellingiri Balachandar
title	Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population
title_short	Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population
title_full	Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population
title_fullStr	Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population
title_full_unstemmed	Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population
title_sort	autism spectrum disorder (asd)-a case-control study to investigate the prenatal, perinatal and neonatal factors in indian population
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9cb54dcdfade4229b6c5fbbabb471a1c
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Autism spectrum disorder (ASD)-a case-control study to investigate the prenatal, perinatal and neonatal factors in Indian Population

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