The Pseudo-Symmetric <i>N</i>-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation

Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric hydroxyethylamine core and heteroarylcarboxyamide moieties. The simple synthetic pathway furnished nine compounds in a few...

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Autores principales:	Rosarita D’Orsi, Maria Funicello, Teresa Laurita, Paolo Lupattelli, Federico Berti, Lucia Chiummiento
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV-protease inhibitors pseudo-symmetric core heteroaryl carboxyamides synthesis biological screening modeling Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9cb7dd769a6d4caca673db4e89ccd6f3
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The Pseudo-Symmetric <i>N</i>-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation

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