Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer

Objective. Adenocarcinoma with mixed subtypes (AM) is a histological classification based on the WHO classification. We aimed to compare the prognosis among AM, classic adenocarcinoma (CA), mucinous adenocarcinoma (MAC), and signet-ring cell carcinoma (SRCC) in early and advanced gastric cancer (EGC...

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Autores principales:	Xixian Zhao, Yizhang Li, Zhenwei Yang, Hailin Zhang, Hongling Wang, Jun Lin, Jing Liu, Qiu Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/9cb7f5d527244167ad5dafb1c32dec5f
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spelling	oai:doaj.org-article:9cb7f5d527244167ad5dafb1c32dec5f2021-11-08T02:36:47ZAdenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer2291-279710.1155/2021/8497305https://doaj.org/article/9cb7f5d527244167ad5dafb1c32dec5f2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8497305https://doaj.org/toc/2291-2797Objective. Adenocarcinoma with mixed subtypes (AM) is a histological classification based on the WHO classification. We aimed to compare the prognosis among AM, classic adenocarcinoma (CA), mucinous adenocarcinoma (MAC), and signet-ring cell carcinoma (SRCC) in early and advanced gastric cancer (EGC and AGC), respectively. Methods. The Surveillance, Epidemiology, and End Results (SEER) database was queried from 2001 to 2016. Univariate and multivariate Cox analyses were performed to compare prognosis between AM and histologic subtypes of CA, SRCC, and MAC in ECG and ACG. A nomogram was established to predict the cancer-specific survival (CSS) of gastric cancer (GC) patients with AM. C-index, calibration curves, and receiver operating characteristic (ROC) and decision curve analysis (DCA) curves were applied to examine the accuracy and clinical benefits. Results. In the prognosis among these four histological subtypes in EGC patients, there are no differences. For AGC patients, AM had a significantly poorer prognosis compared with CA and MAC (P=0.003, 0.029) but similar prognosis to SRCC. A nomogram based on race, T stage, N stage, M stage, and surgical modalities was proposed to predict 1- and 3-year CSS for GC patients with AM (C-index: training cohort: 0.804, validation cohort: 0.748. 1- and 3-year CSS AUC: training cohort: 0.871 and 0.914, validation cohort: 0.810 and 0.798). 1- and 3-year CSS DCA curves showed good net benefits. Conclusions. EGC patients with AM had similar survival to those with CA, MAC, and SRCC. AM was an independent predictor of poor prognosis in AGC. A nomogram for predicting the prognosis of GC patients with AM was proposed to quantitatively assess the long-term survival.Xixian ZhaoYizhang LiZhenwei YangHailin ZhangHongling WangJun LinJing LiuQiu ZhaoHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENCanadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Xixian Zhao Yizhang Li Zhenwei Yang Hailin Zhang Hongling Wang Jun Lin Jing Liu Qiu Zhao Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
description	Objective. Adenocarcinoma with mixed subtypes (AM) is a histological classification based on the WHO classification. We aimed to compare the prognosis among AM, classic adenocarcinoma (CA), mucinous adenocarcinoma (MAC), and signet-ring cell carcinoma (SRCC) in early and advanced gastric cancer (EGC and AGC), respectively. Methods. The Surveillance, Epidemiology, and End Results (SEER) database was queried from 2001 to 2016. Univariate and multivariate Cox analyses were performed to compare prognosis between AM and histologic subtypes of CA, SRCC, and MAC in ECG and ACG. A nomogram was established to predict the cancer-specific survival (CSS) of gastric cancer (GC) patients with AM. C-index, calibration curves, and receiver operating characteristic (ROC) and decision curve analysis (DCA) curves were applied to examine the accuracy and clinical benefits. Results. In the prognosis among these four histological subtypes in EGC patients, there are no differences. For AGC patients, AM had a significantly poorer prognosis compared with CA and MAC (P=0.003, 0.029) but similar prognosis to SRCC. A nomogram based on race, T stage, N stage, M stage, and surgical modalities was proposed to predict 1- and 3-year CSS for GC patients with AM (C-index: training cohort: 0.804, validation cohort: 0.748. 1- and 3-year CSS AUC: training cohort: 0.871 and 0.914, validation cohort: 0.810 and 0.798). 1- and 3-year CSS DCA curves showed good net benefits. Conclusions. EGC patients with AM had similar survival to those with CA, MAC, and SRCC. AM was an independent predictor of poor prognosis in AGC. A nomogram for predicting the prognosis of GC patients with AM was proposed to quantitatively assess the long-term survival.
format	article
author	Xixian Zhao Yizhang Li Zhenwei Yang Hailin Zhang Hongling Wang Jun Lin Jing Liu Qiu Zhao
author_facet	Xixian Zhao Yizhang Li Zhenwei Yang Hailin Zhang Hongling Wang Jun Lin Jing Liu Qiu Zhao
author_sort	Xixian Zhao
title	Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
title_short	Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
title_full	Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
title_fullStr	Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
title_full_unstemmed	Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer
title_sort	adenocarcinoma with mixed subtypes in the early and advanced gastric cancer
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9cb7f5d527244167ad5dafb1c32dec5f
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Adenocarcinoma with Mixed Subtypes in the Early and Advanced Gastric Cancer

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