Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

Melanie Bahlo and colleagues report a genome-wide association study on the retinal degenerative disease Macular Telangiectasia Type 2, identifying 8 new genome-wide significant loci. Further analyses suggest key roles for genes that transport and synthesize the amino acids serine, glycine and alanin...

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Autores principales:	Roberto Bonelli, Victoria E. Jackson, Aravind Prasad, Jacob E. Munro, Samaneh Farashi, Tjebo F. C. Heeren, Nikolas Pontikos, Lea Scheppke, Martin Friedlander, MacTel Consortium, Catherine A. Egan, Rando Allikmets, Brendan R. E. Ansell, Melanie Bahlo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9cba7a84572b4acc832cac9a6d05482a
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spelling	oai:doaj.org-article:9cba7a84572b4acc832cac9a6d05482a2021-12-02T13:33:44ZIdentification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder10.1038/s42003-021-01788-w2399-3642https://doaj.org/article/9cba7a84572b4acc832cac9a6d05482a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01788-whttps://doaj.org/toc/2399-3642Melanie Bahlo and colleagues report a genome-wide association study on the retinal degenerative disease Macular Telangiectasia Type 2, identifying 8 new genome-wide significant loci. Further analyses suggest key roles for genes that transport and synthesize the amino acids serine, glycine and alanine, providing a more accurate genomic tool for identifying people at risk of the disease.Roberto BonelliVictoria E. JacksonAravind PrasadJacob E. MunroSamaneh FarashiTjebo F. C. HeerenNikolas PontikosLea ScheppkeMartin FriedlanderMacTel ConsortiumCatherine A. EganRando AllikmetsBrendan R. E. AnsellMelanie BahloNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Roberto Bonelli Victoria E. Jackson Aravind Prasad Jacob E. Munro Samaneh Farashi Tjebo F. C. Heeren Nikolas Pontikos Lea Scheppke Martin Friedlander MacTel Consortium Catherine A. Egan Rando Allikmets Brendan R. E. Ansell Melanie Bahlo Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
description	Melanie Bahlo and colleagues report a genome-wide association study on the retinal degenerative disease Macular Telangiectasia Type 2, identifying 8 new genome-wide significant loci. Further analyses suggest key roles for genes that transport and synthesize the amino acids serine, glycine and alanine, providing a more accurate genomic tool for identifying people at risk of the disease.
format	article
author	Roberto Bonelli Victoria E. Jackson Aravind Prasad Jacob E. Munro Samaneh Farashi Tjebo F. C. Heeren Nikolas Pontikos Lea Scheppke Martin Friedlander MacTel Consortium Catherine A. Egan Rando Allikmets Brendan R. E. Ansell Melanie Bahlo
author_facet	Roberto Bonelli Victoria E. Jackson Aravind Prasad Jacob E. Munro Samaneh Farashi Tjebo F. C. Heeren Nikolas Pontikos Lea Scheppke Martin Friedlander MacTel Consortium Catherine A. Egan Rando Allikmets Brendan R. E. Ansell Melanie Bahlo
author_sort	Roberto Bonelli
title	Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
title_short	Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
title_full	Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
title_fullStr	Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
title_full_unstemmed	Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder
title_sort	identification of genetic factors influencing metabolic dysregulation and retinal support for mactel, a retinal disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9cba7a84572b4acc832cac9a6d05482a
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Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

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