Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro

Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage...

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Autores principales: Andrew T. Lombardo, Shane R. Nelson, M. Yusuf Ali, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott, David M. Warshaw
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/9cbbb6d752f74a68bb343e25f12b6f66
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Sumario:Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks.