CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.
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Nature Portfolio
2019
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oai:doaj.org-article:9cbe7f002204495db0cd437d4360e24c2021-12-02T17:02:10ZCAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan10.1038/s41467-019-10968-62041-1723https://doaj.org/article/9cbe7f002204495db0cd437d4360e24c2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10968-6https://doaj.org/toc/2041-1723Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.Claire VenninPauline MélénecRomain RouetMax NobisAurélie S. CazetKendelle J. MurphyDavid HerrmannDaniel A. ReedMorghan C. LucasSean C. WarrenZehra ElgundiMark PineseGabriella KalnaDaniel RodenMonisha SamuelAnaiis ZaratzianShane T. GreyAndrew Da SilvaWilfred LeungAustralian Pancreatic Genome Initiative (APGI)Suresh MathivananYingxiao WangAnthony W. BraithwaiteDaniel ChristAles BendaAshleigh ParkinPhoebe A. PhillipsJohn M. WhitelockAnthony J. GillOwen J. SansomDavid R. CroucherBenjamin L. ParkerMarina PajicJennifer P. MortonThomas R. CoxPaul TimpsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-22 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Claire Vennin Pauline Mélénec Romain Rouet Max Nobis Aurélie S. Cazet Kendelle J. Murphy David Herrmann Daniel A. Reed Morghan C. Lucas Sean C. Warren Zehra Elgundi Mark Pinese Gabriella Kalna Daniel Roden Monisha Samuel Anaiis Zaratzian Shane T. Grey Andrew Da Silva Wilfred Leung Australian Pancreatic Genome Initiative (APGI) Suresh Mathivanan Yingxiao Wang Anthony W. Braithwaite Daniel Christ Ales Benda Ashleigh Parkin Phoebe A. Phillips John M. Whitelock Anthony J. Gill Owen J. Sansom David R. Croucher Benjamin L. Parker Marina Pajic Jennifer P. Morton Thomas R. Cox Paul Timpson CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| description |
Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment. |
| format |
article |
| author |
Claire Vennin Pauline Mélénec Romain Rouet Max Nobis Aurélie S. Cazet Kendelle J. Murphy David Herrmann Daniel A. Reed Morghan C. Lucas Sean C. Warren Zehra Elgundi Mark Pinese Gabriella Kalna Daniel Roden Monisha Samuel Anaiis Zaratzian Shane T. Grey Andrew Da Silva Wilfred Leung Australian Pancreatic Genome Initiative (APGI) Suresh Mathivanan Yingxiao Wang Anthony W. Braithwaite Daniel Christ Ales Benda Ashleigh Parkin Phoebe A. Phillips John M. Whitelock Anthony J. Gill Owen J. Sansom David R. Croucher Benjamin L. Parker Marina Pajic Jennifer P. Morton Thomas R. Cox Paul Timpson |
| author_facet |
Claire Vennin Pauline Mélénec Romain Rouet Max Nobis Aurélie S. Cazet Kendelle J. Murphy David Herrmann Daniel A. Reed Morghan C. Lucas Sean C. Warren Zehra Elgundi Mark Pinese Gabriella Kalna Daniel Roden Monisha Samuel Anaiis Zaratzian Shane T. Grey Andrew Da Silva Wilfred Leung Australian Pancreatic Genome Initiative (APGI) Suresh Mathivanan Yingxiao Wang Anthony W. Braithwaite Daniel Christ Ales Benda Ashleigh Parkin Phoebe A. Phillips John M. Whitelock Anthony J. Gill Owen J. Sansom David R. Croucher Benjamin L. Parker Marina Pajic Jennifer P. Morton Thomas R. Cox Paul Timpson |
| author_sort |
Claire Vennin |
| title |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| title_short |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| title_full |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| title_fullStr |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| title_full_unstemmed |
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| title_sort |
caf hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/9cbe7f002204495db0cd437d4360e24c |
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