Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases

Anetta Lasek-Bal, Przemyslaw Puz, Zofia KazibutowskaStroke Unit, Department of Neurology, Medical University of Silesia, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, PolandIntroduction: Hemostasis is affected by interactions between physiological processes, including those connecte...

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Autores principales:	Lasek-Bal A, Puz P, Kazibutowska Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9cbea3ab01174461870f93287a89ae4f
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spelling	oai:doaj.org-article:9cbea3ab01174461870f93287a89ae4f2021-12-02T06:25:43ZElevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases1176-63281178-2021https://doaj.org/article/9cbea3ab01174461870f93287a89ae4f2013-06-01T00:00:00Zhttp://www.dovepress.com/elevated-factor-viii-level-and-stroke-in-patients-without-traditional--a13380https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Anetta Lasek-Bal, Przemyslaw Puz, Zofia KazibutowskaStroke Unit, Department of Neurology, Medical University of Silesia, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, PolandIntroduction: Hemostasis is affected by interactions between physiological processes, including those connected with the coagulation system, whose essence is converting fibrinogen into fibrin. The role of factor VIII (FVIII) consists in activating factor X, which directly participates in the generation of thrombin, which is able to produce stable fibrin, which in turn forms blood clots. There are divergent opinions regarding the significance of high levels of FVIII in stroke pathogenesis.Aim: The aim of our study was to evaluate FVIII activity in individuals with cryptogenic stroke in order to determine a potential relationship between it and cerebral ischemia.Material and methods: Nine patients suffering with stroke were used in this study: six women and three men aged 49–63 years. In all of the patients, the presence of known and potential risk factors for stroke had been excluded during previous diagnostic procedures. These patients accounted for 1.2% of the 719 people who suffered a stroke and were hospitalized in 2011 at the Stroke Unit. FVIII activity was examined in each of the nine qualified subjects within 1–2 months of the occurrence of stroke (the first test) and repeated (the second test) in five patients with abnormal results obtained from the first examination.Results: Increased activity of FVIII was found in 5 out of 9 patients. In patients with abnormal results, elevated FVIII was found in follow-up examinations in the 8th–10th month following stroke. Hemodynamic abnormalities in carotid or cerebral artery (presence of thrombus) were found in 3 of the 5 patients with increased FVIII levels. In the first 24 hours following stroke the neurological state of patients with abnormal FVIII was worse than individuals with normal FVIII activity. The patients with abnormal FVIII levels were found to be more disabled in the examination of self-dependence on the 90th day after stroke.Conclusion: When searching for the causes of stroke, it is worth examining the coagulation system, including FVIII concentration, the abnormality of which may play a significant part in brain ischemia. More research is needed to determine the relationship between abnormal FVIII activity and stroke.Keywords: factor VIII, cryptogenic stroke, hemostasis, risk factorLasek-Bal APuz PKazibutowska ZDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 847-852 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lasek-Bal A Puz P Kazibutowska Z Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
description	Anetta Lasek-Bal, Przemyslaw Puz, Zofia KazibutowskaStroke Unit, Department of Neurology, Medical University of Silesia, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, PolandIntroduction: Hemostasis is affected by interactions between physiological processes, including those connected with the coagulation system, whose essence is converting fibrinogen into fibrin. The role of factor VIII (FVIII) consists in activating factor X, which directly participates in the generation of thrombin, which is able to produce stable fibrin, which in turn forms blood clots. There are divergent opinions regarding the significance of high levels of FVIII in stroke pathogenesis.Aim: The aim of our study was to evaluate FVIII activity in individuals with cryptogenic stroke in order to determine a potential relationship between it and cerebral ischemia.Material and methods: Nine patients suffering with stroke were used in this study: six women and three men aged 49–63 years. In all of the patients, the presence of known and potential risk factors for stroke had been excluded during previous diagnostic procedures. These patients accounted for 1.2% of the 719 people who suffered a stroke and were hospitalized in 2011 at the Stroke Unit. FVIII activity was examined in each of the nine qualified subjects within 1–2 months of the occurrence of stroke (the first test) and repeated (the second test) in five patients with abnormal results obtained from the first examination.Results: Increased activity of FVIII was found in 5 out of 9 patients. In patients with abnormal results, elevated FVIII was found in follow-up examinations in the 8th–10th month following stroke. Hemodynamic abnormalities in carotid or cerebral artery (presence of thrombus) were found in 3 of the 5 patients with increased FVIII levels. In the first 24 hours following stroke the neurological state of patients with abnormal FVIII was worse than individuals with normal FVIII activity. The patients with abnormal FVIII levels were found to be more disabled in the examination of self-dependence on the 90th day after stroke.Conclusion: When searching for the causes of stroke, it is worth examining the coagulation system, including FVIII concentration, the abnormality of which may play a significant part in brain ischemia. More research is needed to determine the relationship between abnormal FVIII activity and stroke.Keywords: factor VIII, cryptogenic stroke, hemostasis, risk factor
format	article
author	Lasek-Bal A Puz P Kazibutowska Z
author_facet	Lasek-Bal A Puz P Kazibutowska Z
author_sort	Lasek-Bal A
title	Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
title_short	Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
title_full	Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
title_fullStr	Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
title_full_unstemmed	Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
title_sort	elevated factor viii level and stroke in patients without traditional risk factors associated with cardiovascular diseases
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/9cbea3ab01174461870f93287a89ae4f
work_keys_str_mv	AT lasekbala elevatedfactorviiilevelandstrokeinpatientswithouttraditionalriskfactorsassociatedwithcardiovasculardiseases AT puzp elevatedfactorviiilevelandstrokeinpatientswithouttraditionalriskfactorsassociatedwithcardiovasculardiseases AT kazibutowskaz elevatedfactorviiilevelandstrokeinpatientswithouttraditionalriskfactorsassociatedwithcardiovasculardiseases
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Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases

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