A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042)

Abstract Dostarlimab is a humanized anti–PD-1 monoclonal antibody. Dostarlimab (JEMPERLI; TSR-042) was recently approved in the USA and in the EU. The presence of neutralizing antibodies (NAbs) is a cause for concern because they block the therapeutic function of the antibody and reduce drug efficac...

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Auteurs principaux: Xiaolong Tom Zhang, Hong Chen, Weiping Shao, Zhongping John Lin, Murad Melhem, Sharon Lu
Format: article
Langue:EN
Publié: SpringerOpen 2021
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Accès en ligne:https://doaj.org/article/9cc562b825a24dee8a7fce5d389aa00c
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