Prevalence and predictors of antibiotic administration during pregnancy and birth.

<h4>Background</h4>Antibiotic treatment during pregnancy and birth is very common. In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in the COPSAC2010 pregnancy cohort, and analyze dependence on social and lifestyle-related factor...

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Autores principales:	Jakob Stokholm, Susanne Schjørring, Louise Pedersen, Anne Louise Bischoff, Nilofar Følsgaard, Charlotte G Carson, Bo L K Chawes, Klaus Bønnelykke, Anne Mølgaard, Karen A Krogfelt, Hans Bisgaard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9cc6d60fe2d5486f9642c2e1967e56d1
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spelling	oai:doaj.org-article:9cc6d60fe2d5486f9642c2e1967e56d12021-11-18T08:42:37ZPrevalence and predictors of antibiotic administration during pregnancy and birth.1932-620310.1371/journal.pone.0082932https://doaj.org/article/9cc6d60fe2d5486f9642c2e1967e56d12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24340068/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Antibiotic treatment during pregnancy and birth is very common. In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in the COPSAC2010 pregnancy cohort, and analyze dependence on social and lifestyle-related factors.<h4>Methods</h4>706 pregnant women from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) pregnancy cohort participated in this analysis. Detailed information on oral antibiotic prescriptions during pregnancy filled at the pharmacy was obtained and verified longitudinally. Information on intrapartum antibiotics, social, and lifestyle-factors was obtained by personal interviews.<h4>Results</h4>The prevalence of antibiotic use was 37% during pregnancy and 33% intrapartum. Lower maternal age at birth; adjusted odds ratio (aOR) 0.94, 95% CI, [0.90-0.98], p = 0.003 and maternal smoking; aOR 1.97, 95% CI, [1.07-3.63], p = 0.030 were associated with use of antibiotics for urinary tract infection during pregnancy. Maternal educational level (low vs. high), aOR 2.32, 95% CI, [1.24-4.35], p = 0.011, maternal asthma; aOR 1.99, 95% CI, [1.33-2.98], p < 0.001 and previous childbirth; aOR 1.80, 95% CI, [1.21-2.66], p = 0.004 were associated with use of antibiotics for respiratory tract infection during pregnancy. Lower gestational age; aOR 0.72, 95% CI, [0.61-0.85], p < 0.001, maternal smoking; aOR 2.84, 95% CI, [1.33-6.06], p = 0.007, and nulliparity; aOR 1.79, 95% CI, [1.06-3.02], p = 0.030 were associated with administration of intrapartum antibiotics in women giving birth vaginally.<h4>Conclusion</h4>Antibiotic administration during pregnancy and birth may be influenced by social and lifestyle-factors. Understanding such risk factors may guide preventive strategies in order to avoid unnecessary use of antibiotics.Jakob StokholmSusanne SchjørringLouise PedersenAnne Louise BischoffNilofar FølsgaardCharlotte G CarsonBo L K ChawesKlaus BønnelykkeAnne MølgaardKaren A KrogfeltHans BisgaardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82932 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jakob Stokholm Susanne Schjørring Louise Pedersen Anne Louise Bischoff Nilofar Følsgaard Charlotte G Carson Bo L K Chawes Klaus Bønnelykke Anne Mølgaard Karen A Krogfelt Hans Bisgaard Prevalence and predictors of antibiotic administration during pregnancy and birth.
description	<h4>Background</h4>Antibiotic treatment during pregnancy and birth is very common. In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in the COPSAC2010 pregnancy cohort, and analyze dependence on social and lifestyle-related factors.<h4>Methods</h4>706 pregnant women from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) pregnancy cohort participated in this analysis. Detailed information on oral antibiotic prescriptions during pregnancy filled at the pharmacy was obtained and verified longitudinally. Information on intrapartum antibiotics, social, and lifestyle-factors was obtained by personal interviews.<h4>Results</h4>The prevalence of antibiotic use was 37% during pregnancy and 33% intrapartum. Lower maternal age at birth; adjusted odds ratio (aOR) 0.94, 95% CI, [0.90-0.98], p = 0.003 and maternal smoking; aOR 1.97, 95% CI, [1.07-3.63], p = 0.030 were associated with use of antibiotics for urinary tract infection during pregnancy. Maternal educational level (low vs. high), aOR 2.32, 95% CI, [1.24-4.35], p = 0.011, maternal asthma; aOR 1.99, 95% CI, [1.33-2.98], p < 0.001 and previous childbirth; aOR 1.80, 95% CI, [1.21-2.66], p = 0.004 were associated with use of antibiotics for respiratory tract infection during pregnancy. Lower gestational age; aOR 0.72, 95% CI, [0.61-0.85], p < 0.001, maternal smoking; aOR 2.84, 95% CI, [1.33-6.06], p = 0.007, and nulliparity; aOR 1.79, 95% CI, [1.06-3.02], p = 0.030 were associated with administration of intrapartum antibiotics in women giving birth vaginally.<h4>Conclusion</h4>Antibiotic administration during pregnancy and birth may be influenced by social and lifestyle-factors. Understanding such risk factors may guide preventive strategies in order to avoid unnecessary use of antibiotics.
format	article
author	Jakob Stokholm Susanne Schjørring Louise Pedersen Anne Louise Bischoff Nilofar Følsgaard Charlotte G Carson Bo L K Chawes Klaus Bønnelykke Anne Mølgaard Karen A Krogfelt Hans Bisgaard
author_facet	Jakob Stokholm Susanne Schjørring Louise Pedersen Anne Louise Bischoff Nilofar Følsgaard Charlotte G Carson Bo L K Chawes Klaus Bønnelykke Anne Mølgaard Karen A Krogfelt Hans Bisgaard
author_sort	Jakob Stokholm
title	Prevalence and predictors of antibiotic administration during pregnancy and birth.
title_short	Prevalence and predictors of antibiotic administration during pregnancy and birth.
title_full	Prevalence and predictors of antibiotic administration during pregnancy and birth.
title_fullStr	Prevalence and predictors of antibiotic administration during pregnancy and birth.
title_full_unstemmed	Prevalence and predictors of antibiotic administration during pregnancy and birth.
title_sort	prevalence and predictors of antibiotic administration during pregnancy and birth.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9cc6d60fe2d5486f9642c2e1967e56d1
work_keys_str_mv	AT jakobstokholm prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT susanneschjørring prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT louisepedersen prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT annelouisebischoff prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT nilofarfølsgaard prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT charlottegcarson prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT bolkchawes prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT klausbønnelykke prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT annemølgaard prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT karenakrogfelt prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth AT hansbisgaard prevalenceandpredictorsofantibioticadministrationduringpregnancyandbirth
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Prevalence and predictors of antibiotic administration during pregnancy and birth.

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