In vitro Effect of Silver Nanoparticles on Blastocystis hominis

Mohamed Saad Younis,1 Eman Abd el rahman Abououf,1 Ali El saeed Ali,1 Sara Mohamed Abd elhady,2 Rita Maher Wassef2 1Medical Parasitology Department, Faculty of Medicine, Benha University, Benha, Egypt; 2Medical Parasitology Department, Faculty of Medicine, Helwan University, Cairo, EgyptCorresponden...

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Autores principales:	Younis SA, Abououf EA, Ali AE, Abd elhady SM, Wassef RM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	blastocystis hominis eosin brilliant cresyl blue stain metronidazole silver nanoparticles. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9cca3760c07340acab33ce74410a4918
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spelling	oai:doaj.org-article:9cca3760c07340acab33ce74410a49182021-12-02T11:06:48ZIn vitro Effect of Silver Nanoparticles on Blastocystis hominis1178-2013https://doaj.org/article/9cca3760c07340acab33ce74410a49182020-10-01T00:00:00Zhttps://www.dovepress.com/in-vitro-effect-of-silver-nanoparticles-on-blastocystis-hominis-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Saad Younis,1 Eman Abd el rahman Abououf,1 Ali El saeed Ali,1 Sara Mohamed Abd elhady,2 Rita Maher Wassef2 1Medical Parasitology Department, Faculty of Medicine, Benha University, Benha, Egypt; 2Medical Parasitology Department, Faculty of Medicine, Helwan University, Cairo, EgyptCorrespondence: Rita Maher WassefMedical Parasitology Department, Faculty of Medicine, Helwan University, 30 Street 276 New Maadi, Cairo, EgyptTel +201005782994Fax +20225193381Email rita.wassef@med.helwan.edu.egIntroduction: This study aims to assess the efficacy of silver nanoparticles (Ag Nps) alone and combined with metronidazole (Ag Nps + MTZ) as potential alternative therapeutic agents for Blastocystis hominis.Methods: The parasites were challenged with Ag Nps, Ag Nps + MTZ and MTZ. To assess the efficacy of drugs, counting of viable parasites was done after 1, 2, and 3 hours of adding the drugs.Results: Blastocystis hominis count was reduced by 20.72%, 28.23%, and 18.92% after one hour of adding Ag Nps, Ag Nps + MTZ, and MTZ, respectively. Cysts count was further reduced by 51.49%, 61.61%, and 40.78% after 2 hours and by 71.69%, 79.67%, and 62.65% after 3 hours of adding the drugs in the same order, respectively.Conclusion: There was a statistically significant difference (P< 0.05) in the in vitro growth inhibition of the parasite over the different time intervals when using the tested drugs against the control drug.Keywords: Blastocystis hominis, eosin brilliant cresyl blue stain, metronidazole, silver nanoparticlesYounis SAAbououf EAAli AEAbd elhady SMWassef RMDove Medical Pressarticleblastocystis hominiseosin brilliant cresyl blue stainmetronidazolesilver nanoparticles.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8167-8173 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	blastocystis hominis eosin brilliant cresyl blue stain metronidazole silver nanoparticles. Medicine (General) R5-920
spellingShingle	blastocystis hominis eosin brilliant cresyl blue stain metronidazole silver nanoparticles. Medicine (General) R5-920 Younis SA Abououf EA Ali AE Abd elhady SM Wassef RM In vitro Effect of Silver Nanoparticles on Blastocystis hominis
description	Mohamed Saad Younis,1 Eman Abd el rahman Abououf,1 Ali El saeed Ali,1 Sara Mohamed Abd elhady,2 Rita Maher Wassef2 1Medical Parasitology Department, Faculty of Medicine, Benha University, Benha, Egypt; 2Medical Parasitology Department, Faculty of Medicine, Helwan University, Cairo, EgyptCorrespondence: Rita Maher WassefMedical Parasitology Department, Faculty of Medicine, Helwan University, 30 Street 276 New Maadi, Cairo, EgyptTel +201005782994Fax +20225193381Email rita.wassef@med.helwan.edu.egIntroduction: This study aims to assess the efficacy of silver nanoparticles (Ag Nps) alone and combined with metronidazole (Ag Nps + MTZ) as potential alternative therapeutic agents for Blastocystis hominis.Methods: The parasites were challenged with Ag Nps, Ag Nps + MTZ and MTZ. To assess the efficacy of drugs, counting of viable parasites was done after 1, 2, and 3 hours of adding the drugs.Results: Blastocystis hominis count was reduced by 20.72%, 28.23%, and 18.92% after one hour of adding Ag Nps, Ag Nps + MTZ, and MTZ, respectively. Cysts count was further reduced by 51.49%, 61.61%, and 40.78% after 2 hours and by 71.69%, 79.67%, and 62.65% after 3 hours of adding the drugs in the same order, respectively.Conclusion: There was a statistically significant difference (P< 0.05) in the in vitro growth inhibition of the parasite over the different time intervals when using the tested drugs against the control drug.Keywords: Blastocystis hominis, eosin brilliant cresyl blue stain, metronidazole, silver nanoparticles
format	article
author	Younis SA Abououf EA Ali AE Abd elhady SM Wassef RM
author_facet	Younis SA Abououf EA Ali AE Abd elhady SM Wassef RM
author_sort	Younis SA
title	In vitro Effect of Silver Nanoparticles on Blastocystis hominis
title_short	In vitro Effect of Silver Nanoparticles on Blastocystis hominis
title_full	In vitro Effect of Silver Nanoparticles on Blastocystis hominis
title_fullStr	In vitro Effect of Silver Nanoparticles on Blastocystis hominis
title_full_unstemmed	In vitro Effect of Silver Nanoparticles on Blastocystis hominis
title_sort	in vitro effect of silver nanoparticles on blastocystis hominis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9cca3760c07340acab33ce74410a4918
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In vitro Effect of Silver Nanoparticles on Blastocystis hominis

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