SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS

The рарег presents the results of measurements of cytokine levels in serum and conditioned medium of PBMC cultures from the patients with atopic dermatitis with the exacerbation and remission in comparison with the healthy donors. We have shown that the serum levels of the key cytokines IL-5 and IL-...

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Autores principales:	A. N. Silkov, T. V. Kovalevskaya-Kutcheryavenko, S. A. Falaleyeva, J. A. Shevchenko, V. M. Nepomnyaschikh, S. V. Sennikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	atopic dermatitis cytokines serum conditioned medium Science Q
Acceso en línea:	https://doaj.org/article/9cca6afde04042d88385257bad827212
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spelling	oai:doaj.org-article:9cca6afde04042d88385257bad8272122021-11-23T06:14:19ZSERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS2541-94202587-9596https://doaj.org/article/9cca6afde04042d88385257bad8272122012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/912https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The рарег presents the results of measurements of cytokine levels in serum and conditioned medium of PBMC cultures from the patients with atopic dermatitis with the exacerbation and remission in comparison with the healthy donors. We have shown that the serum levels of the key cytokines IL-5 and IL-13, proinflammatory cytokines IL-1β and IL-6 and the main Th1 cytokine — IFNγ — were higher compared to healthy donors. In the conditioned media of peripheral blood mononuclear cells in contrast, we have found a significant decrease of the spontaneous secretion of key cytokines IL-10 and IL-17. We have shown that the stimulated secretion of IL-5 and IL-13, IL-12 and INF-γ is significantly reduced in comparison with the control level. Only IL-1β revealed a statistically significant higher level of stimulated secretion without exacerbation of atopic dermatitis. The contemporary therapy has no effect on cytokine production.A. N. SilkovT. V. Kovalevskaya-KutcheryavenkoS. A. FalaleyevaJ. A. ShevchenkoV. M. NepomnyaschikhS. V. SennikovScientific Сentre for Family Health and Human Reproduction Problemsarticleatopic dermatitiscytokinesserumconditioned mediumScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 175-179 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	atopic dermatitis cytokines serum conditioned medium Science Q
spellingShingle	atopic dermatitis cytokines serum conditioned medium Science Q A. N. Silkov T. V. Kovalevskaya-Kutcheryavenko S. A. Falaleyeva J. A. Shevchenko V. M. Nepomnyaschikh S. V. Sennikov SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS
description	The рарег presents the results of measurements of cytokine levels in serum and conditioned medium of PBMC cultures from the patients with atopic dermatitis with the exacerbation and remission in comparison with the healthy donors. We have shown that the serum levels of the key cytokines IL-5 and IL-13, proinflammatory cytokines IL-1β and IL-6 and the main Th1 cytokine — IFNγ — were higher compared to healthy donors. In the conditioned media of peripheral blood mononuclear cells in contrast, we have found a significant decrease of the spontaneous secretion of key cytokines IL-10 and IL-17. We have shown that the stimulated secretion of IL-5 and IL-13, IL-12 and INF-γ is significantly reduced in comparison with the control level. Only IL-1β revealed a statistically significant higher level of stimulated secretion without exacerbation of atopic dermatitis. The contemporary therapy has no effect on cytokine production.
format	article
author	A. N. Silkov T. V. Kovalevskaya-Kutcheryavenko S. A. Falaleyeva J. A. Shevchenko V. M. Nepomnyaschikh S. V. Sennikov
author_facet	A. N. Silkov T. V. Kovalevskaya-Kutcheryavenko S. A. Falaleyeva J. A. Shevchenko V. M. Nepomnyaschikh S. V. Sennikov
author_sort	A. N. Silkov
title	SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS
title_short	SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS
title_full	SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS
title_fullStr	SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS
title_full_unstemmed	SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS
title_sort	serum level and production of cytokines by pbmc in patients with atopic dermatitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/9cca6afde04042d88385257bad827212
work_keys_str_mv	AT ansilkov serumlevelandproductionofcytokinesbypbmcinpatientswithatopicdermatitis AT tvkovalevskayakutcheryavenko serumlevelandproductionofcytokinesbypbmcinpatientswithatopicdermatitis AT safalaleyeva serumlevelandproductionofcytokinesbypbmcinpatientswithatopicdermatitis AT jashevchenko serumlevelandproductionofcytokinesbypbmcinpatientswithatopicdermatitis AT vmnepomnyaschikh serumlevelandproductionofcytokinesbypbmcinpatientswithatopicdermatitis AT svsennikov serumlevelandproductionofcytokinesbypbmcinpatientswithatopicdermatitis
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SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS

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