Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

Abstract Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growth, but also to contribute to tissue damage, shorte...

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Autores principales:	Gilles Vanwalleghem, Yannick Morias, Alain Beschin, David E. Szymkowski, Etienne Pays
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ccb1178e6e74b48a7a7e05f9c0d3d11
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spelling	oai:doaj.org-article:9ccb1178e6e74b48a7a7e05f9c0d3d112021-12-02T12:30:17ZTrypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine10.1038/s41598-017-06496-22045-2322https://doaj.org/article/9ccb1178e6e74b48a7a7e05f9c0d3d112017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06496-2https://doaj.org/toc/2045-2322Abstract Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growth, but also to contribute to tissue damage, shortening the survival time of infected mice. Using a dominant-negative version of TNF to discriminate between the effects of the membrane-form versus the soluble form of TNF, we show that the second form is involved in neither parasite control nor induction of liver injury. Therefore, soluble TNF is likely not a major contributor to disease outcome. We propose that membrane-bound TNF is responsible for both T. brucei control and host pathology.Gilles VanwalleghemYannick MoriasAlain BeschinDavid E. SzymkowskiEtienne PaysNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gilles Vanwalleghem Yannick Morias Alain Beschin David E. Szymkowski Etienne Pays Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
description	Abstract Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growth, but also to contribute to tissue damage, shortening the survival time of infected mice. Using a dominant-negative version of TNF to discriminate between the effects of the membrane-form versus the soluble form of TNF, we show that the second form is involved in neither parasite control nor induction of liver injury. Therefore, soluble TNF is likely not a major contributor to disease outcome. We propose that membrane-bound TNF is responsible for both T. brucei control and host pathology.
format	article
author	Gilles Vanwalleghem Yannick Morias Alain Beschin David E. Szymkowski Etienne Pays
author_facet	Gilles Vanwalleghem Yannick Morias Alain Beschin David E. Szymkowski Etienne Pays
author_sort	Gilles Vanwalleghem
title	Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
title_short	Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
title_full	Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
title_fullStr	Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
title_full_unstemmed	Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
title_sort	trypanosoma brucei growth control by tnf in mammalian host is independent of the soluble form of the cytokine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9ccb1178e6e74b48a7a7e05f9c0d3d11
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Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

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