Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.

The main purpose of the current trial was to test if a brief trauma-focused cognitive-behaviour therapy protocol (prolonged exposure; PE) provided within 72 h after a traumatic event could be effective in decreasing the incidence of post-traumatic stress disorder (PTSD), thus replicating and extendi...

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Autores principales:	Maria Bragesjö, Filip K Arnberg, Erik Andersson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ccbe70bb4374070b5aa7c61cbb42f51
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spelling	oai:doaj.org-article:9ccbe70bb4374070b5aa7c61cbb42f512021-11-25T06:19:02ZPrevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.1932-620310.1371/journal.pone.0251898https://doaj.org/article/9ccbe70bb4374070b5aa7c61cbb42f512021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251898https://doaj.org/toc/1932-6203The main purpose of the current trial was to test if a brief trauma-focused cognitive-behaviour therapy protocol (prolonged exposure; PE) provided within 72 h after a traumatic event could be effective in decreasing the incidence of post-traumatic stress disorder (PTSD), thus replicating and extending the findings from an earlier trial. After a pilot study (N = 10), which indicated feasible and deliverable study procedures and interventions, we launched an RCT with a target sample size of 352 participants randomised to either three sessions of PE or non-directive support. Due to an unforeseen major reorganisation at the hospital, the RCT was discontinued after 32 included participants. In this paper, we highlight obstacles and lessons learned from our feasibility work that are relevant for preventive psychological interventions for PTSD in emergency settings. One important finding was the high degree of attrition, and only 75% and 34%, respectively, came back for the 2-month and 6-month assessments. There were also difficulties in reaching eligible patients immediately after the event. Based on our experiences, we envisage that alternative models of implementation might overcome these obstacles, for example, with remote delivery of both assessments and interventions via the internet or smartphones combined with multiple recruitment procedures. Lessons learned from this terminated RCT are discussed in depth.Maria BragesjöFilip K ArnbergErik AnderssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251898 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Bragesjö Filip K Arnberg Erik Andersson Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
description	The main purpose of the current trial was to test if a brief trauma-focused cognitive-behaviour therapy protocol (prolonged exposure; PE) provided within 72 h after a traumatic event could be effective in decreasing the incidence of post-traumatic stress disorder (PTSD), thus replicating and extending the findings from an earlier trial. After a pilot study (N = 10), which indicated feasible and deliverable study procedures and interventions, we launched an RCT with a target sample size of 352 participants randomised to either three sessions of PE or non-directive support. Due to an unforeseen major reorganisation at the hospital, the RCT was discontinued after 32 included participants. In this paper, we highlight obstacles and lessons learned from our feasibility work that are relevant for preventive psychological interventions for PTSD in emergency settings. One important finding was the high degree of attrition, and only 75% and 34%, respectively, came back for the 2-month and 6-month assessments. There were also difficulties in reaching eligible patients immediately after the event. Based on our experiences, we envisage that alternative models of implementation might overcome these obstacles, for example, with remote delivery of both assessments and interventions via the internet or smartphones combined with multiple recruitment procedures. Lessons learned from this terminated RCT are discussed in depth.
format	article
author	Maria Bragesjö Filip K Arnberg Erik Andersson
author_facet	Maria Bragesjö Filip K Arnberg Erik Andersson
author_sort	Maria Bragesjö
title	Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
title_short	Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
title_full	Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
title_fullStr	Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
title_full_unstemmed	Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.
title_sort	prevention of post-traumatic stress disorder: lessons learned from a terminated rct of prolonged exposure.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9ccbe70bb4374070b5aa7c61cbb42f51
work_keys_str_mv	AT mariabragesjo preventionofposttraumaticstressdisorderlessonslearnedfromaterminatedrctofprolongedexposure AT filipkarnberg preventionofposttraumaticstressdisorderlessonslearnedfromaterminatedrctofprolongedexposure AT erikandersson preventionofposttraumaticstressdisorderlessonslearnedfromaterminatedrctofprolongedexposure
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Prevention of post-traumatic stress disorder: Lessons learned from a terminated RCT of prolonged exposure.

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