Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for <i>de novo</i> cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the abili...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
MDPI AG
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/9ccc37e1b6d94020b0713f3c29fd816d |
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| Summary: | The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for <i>de novo</i> cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the ability of the tested bioink to form a cartilage within five to six weeks after the subcutaneous scaffold implantation. Certain areas of cartilage formation were detected as early as in one week. The resulting cartilage tissue had a distinctive structure with groups of isogenic cells as well as a high content of glycosaminoglycans and type II collagen. |
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