Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes

The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for <i>de novo</i> cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the abili...

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Autores principales:	Evgeny E. Beketov, Elena V. Isaeva, Nina D. Yakovleva, Grigory A. Demyashkin, Nadezhda V. Arguchinskaya, Anastas A. Kisel, Tatiana S. Lagoda, Egor P. Malakhov, Valentin I. Kharlov, Egor O. Osidak, Sergey P. Domogatsky, Sergey A. Ivanov, Petr V. Shegay, Andrey D. Kaprin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biofabrication bioprinting hydrogel collagen bioink scaffold Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9ccc37e1b6d94020b0713f3c29fd816d
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spelling	oai:doaj.org-article:9ccc37e1b6d94020b0713f3c29fd816d2021-11-11T16:49:40ZBioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes10.3390/ijms2221113511422-00671661-6596https://doaj.org/article/9ccc37e1b6d94020b0713f3c29fd816d2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11351https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for <i>de novo</i> cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the ability of the tested bioink to form a cartilage within five to six weeks after the subcutaneous scaffold implantation. Certain areas of cartilage formation were detected as early as in one week. The resulting cartilage tissue had a distinctive structure with groups of isogenic cells as well as a high content of glycosaminoglycans and type II collagen.Evgeny E. BeketovElena V. IsaevaNina D. YakovlevaGrigory A. DemyashkinNadezhda V. ArguchinskayaAnastas A. KiselTatiana S. LagodaEgor P. MalakhovValentin I. KharlovEgor O. OsidakSergey P. DomogatskySergey A. IvanovPetr V. ShegayAndrey D. KaprinMDPI AGarticlebiofabricationbioprintinghydrogelcollagenbioinkscaffoldBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11351, p 11351 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biofabrication bioprinting hydrogel collagen bioink scaffold Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	biofabrication bioprinting hydrogel collagen bioink scaffold Biology (General) QH301-705.5 Chemistry QD1-999 Evgeny E. Beketov Elena V. Isaeva Nina D. Yakovleva Grigory A. Demyashkin Nadezhda V. Arguchinskaya Anastas A. Kisel Tatiana S. Lagoda Egor P. Malakhov Valentin I. Kharlov Egor O. Osidak Sergey P. Domogatsky Sergey A. Ivanov Petr V. Shegay Andrey D. Kaprin Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
description	The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for <i>de novo</i> cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the ability of the tested bioink to form a cartilage within five to six weeks after the subcutaneous scaffold implantation. Certain areas of cartilage formation were detected as early as in one week. The resulting cartilage tissue had a distinctive structure with groups of isogenic cells as well as a high content of glycosaminoglycans and type II collagen.
format	article
author	Evgeny E. Beketov Elena V. Isaeva Nina D. Yakovleva Grigory A. Demyashkin Nadezhda V. Arguchinskaya Anastas A. Kisel Tatiana S. Lagoda Egor P. Malakhov Valentin I. Kharlov Egor O. Osidak Sergey P. Domogatsky Sergey A. Ivanov Petr V. Shegay Andrey D. Kaprin
author_facet	Evgeny E. Beketov Elena V. Isaeva Nina D. Yakovleva Grigory A. Demyashkin Nadezhda V. Arguchinskaya Anastas A. Kisel Tatiana S. Lagoda Egor P. Malakhov Valentin I. Kharlov Egor O. Osidak Sergey P. Domogatsky Sergey A. Ivanov Petr V. Shegay Andrey D. Kaprin
author_sort	Evgeny E. Beketov
title	Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
title_short	Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
title_full	Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
title_fullStr	Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
title_full_unstemmed	Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes
title_sort	bioprinting of cartilage with bioink based on high-concentration collagen and chondrocytes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9ccc37e1b6d94020b0713f3c29fd816d
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Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes

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