Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors

Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors

Abstract Prostate cancer cells are characterized by a remarkably low proliferative rate and the production of high levels of prostate-specific proteases. Protein-based toxins are attractive candidates for prostate cancer therapy because they kill cells via proliferation-independent mechanisms. Howev...

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Autores principales: O. C. Rogers, D. M. Rosen, L. Antony, H. M. Harper, D. Das, X. Yang, I. Minn, R. C. Mease, M. G. Pomper, S. R. Denmeade
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/9ccc999bbc6e4ef58648953c074fc96c
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