Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities

Abstract Antimicrobial resistance seriously threatened human health, and new antimicrobial agents are desperately needed. As one of the largest classes of plant secondary metabolite, flavonoids can be widely found in various parts of the plant, and their antibacterial activities have been increasing...

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Autores principales:	Ganjun Yuan, Yingying Guan, Houqin Yi, Shan Lai, Yifei Sun, Seng Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9cccba7910f2494b970e125c594e6c98
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spelling	oai:doaj.org-article:9cccba7910f2494b970e125c594e6c982021-12-02T15:52:25ZAntibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities10.1038/s41598-021-90035-72045-2322https://doaj.org/article/9cccba7910f2494b970e125c594e6c982021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90035-7https://doaj.org/toc/2045-2322Abstract Antimicrobial resistance seriously threatened human health, and new antimicrobial agents are desperately needed. As one of the largest classes of plant secondary metabolite, flavonoids can be widely found in various parts of the plant, and their antibacterial activities have been increasingly paid attention to. Based on the physicochemical parameters and antibacterial activities of sixty-six flavonoids reported, two regression equations between their ACD/LogP or LogD7.40 and their minimum inhibitory concentrations (MICs) to gram-positive bacteria were established with the correlation coefficients above 0.93, and then were verified by another sixty-eight flavonoids reported. From these two equations, the MICs of most flavonoids against gram-positive bacteria could be roughly calculated from their ACD/LogP or LogD7.40, and the minimum MIC was predicted as approximately 10.2 or 4.8 μM, more likely falls into the range from 2.6 to 10.2 μM, or from 1.2 to 4.8 μM. Simultaneously, both tendentiously concave regression curves indicated that the lipophilicity is a key factor for flavonoids against gram-positive bacteria. Combined with the literature analyses, the results also suggested that the cell membrane is the main site of flavonoids acting on gram-positive bacteria, and which likely involves the damage of phospholipid bilayers, the inhibition of the respiratory chain or the ATP synthesis, or some others.Ganjun YuanYingying GuanHouqin YiShan LaiYifei SunSeng CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ganjun Yuan Yingying Guan Houqin Yi Shan Lai Yifei Sun Seng Cao Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
description	Abstract Antimicrobial resistance seriously threatened human health, and new antimicrobial agents are desperately needed. As one of the largest classes of plant secondary metabolite, flavonoids can be widely found in various parts of the plant, and their antibacterial activities have been increasingly paid attention to. Based on the physicochemical parameters and antibacterial activities of sixty-six flavonoids reported, two regression equations between their ACD/LogP or LogD7.40 and their minimum inhibitory concentrations (MICs) to gram-positive bacteria were established with the correlation coefficients above 0.93, and then were verified by another sixty-eight flavonoids reported. From these two equations, the MICs of most flavonoids against gram-positive bacteria could be roughly calculated from their ACD/LogP or LogD7.40, and the minimum MIC was predicted as approximately 10.2 or 4.8 μM, more likely falls into the range from 2.6 to 10.2 μM, or from 1.2 to 4.8 μM. Simultaneously, both tendentiously concave regression curves indicated that the lipophilicity is a key factor for flavonoids against gram-positive bacteria. Combined with the literature analyses, the results also suggested that the cell membrane is the main site of flavonoids acting on gram-positive bacteria, and which likely involves the damage of phospholipid bilayers, the inhibition of the respiratory chain or the ATP synthesis, or some others.
format	article
author	Ganjun Yuan Yingying Guan Houqin Yi Shan Lai Yifei Sun Seng Cao
author_facet	Ganjun Yuan Yingying Guan Houqin Yi Shan Lai Yifei Sun Seng Cao
author_sort	Ganjun Yuan
title	Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
title_short	Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
title_full	Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
title_fullStr	Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
title_full_unstemmed	Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
title_sort	antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9cccba7910f2494b970e125c594e6c98
work_keys_str_mv	AT ganjunyuan antibacterialactivityandmechanismofplantflavonoidstogrampositivebacteriapredictedfromtheirlipophilicities AT yingyingguan antibacterialactivityandmechanismofplantflavonoidstogrampositivebacteriapredictedfromtheirlipophilicities AT houqinyi antibacterialactivityandmechanismofplantflavonoidstogrampositivebacteriapredictedfromtheirlipophilicities AT shanlai antibacterialactivityandmechanismofplantflavonoidstogrampositivebacteriapredictedfromtheirlipophilicities AT yifeisun antibacterialactivityandmechanismofplantflavonoidstogrampositivebacteriapredictedfromtheirlipophilicities AT sengcao antibacterialactivityandmechanismofplantflavonoidstogrampositivebacteriapredictedfromtheirlipophilicities
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Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities

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