p190RhoGAP proteins contain pseudoGTPase domains

A growing number of ‘pseudoenzymes’ with a regulatory role in signal transduction processes but without catalytic activity are being identified. Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influence RhoGAP act...

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Auteurs principaux:	Amy L. Stiegler, Titus J. Boggon
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9cd51f99991242e7909c8e191046ed0e
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id	oai:doaj.org-article:9cd51f99991242e7909c8e191046ed0e
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spelling	oai:doaj.org-article:9cd51f99991242e7909c8e191046ed0e2021-12-02T15:38:47Zp190RhoGAP proteins contain pseudoGTPase domains10.1038/s41467-017-00483-x2041-1723https://doaj.org/article/9cd51f99991242e7909c8e191046ed0e2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00483-xhttps://doaj.org/toc/2041-1723A growing number of ‘pseudoenzymes’ with a regulatory role in signal transduction processes but without catalytic activity are being identified. Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influence RhoGAP activity.Amy L. StieglerTitus J. BoggonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy L. Stiegler Titus J. Boggon p190RhoGAP proteins contain pseudoGTPase domains
description	A growing number of ‘pseudoenzymes’ with a regulatory role in signal transduction processes but without catalytic activity are being identified. Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influence RhoGAP activity.
format	article
author	Amy L. Stiegler Titus J. Boggon
author_facet	Amy L. Stiegler Titus J. Boggon
author_sort	Amy L. Stiegler
title	p190RhoGAP proteins contain pseudoGTPase domains
title_short	p190RhoGAP proteins contain pseudoGTPase domains
title_full	p190RhoGAP proteins contain pseudoGTPase domains
title_fullStr	p190RhoGAP proteins contain pseudoGTPase domains
title_full_unstemmed	p190RhoGAP proteins contain pseudoGTPase domains
title_sort	p190rhogap proteins contain pseudogtpase domains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9cd51f99991242e7909c8e191046ed0e
work_keys_str_mv	AT amylstiegler p190rhogapproteinscontainpseudogtpasedomains AT titusjboggon p190rhogapproteinscontainpseudogtpasedomains
_version_	1718386063388442624

p190RhoGAP proteins contain pseudoGTPase domains

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