Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer

Hong Li1, Min Gong1, Aiping Yang1, Jian Ma2, Xiangde Li3, Yonggang Yan11School of Physical Science and Technology, Sichuan University, Chengdu People&rsquo;s Republic of China; 2Hospital of Stomatology, Tongji University, ShanghaiPeople&rsquo;s Republic of China; 3Key Laboratory for...

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Autores principales:	Li XD, Ma J, Gong M,Yang AP, Li H, Yan YG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9cd5766750834774a9bf9c3f83a162e3
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spelling	oai:doaj.org-article:9cd5766750834774a9bf9c3f83a162e32021-12-02T00:58:21ZDegradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer1176-91141178-2013https://doaj.org/article/9cd5766750834774a9bf9c3f83a162e32012-03-01T00:00:00Zhttp://www.dovepress.com/degradable-biocomposite-of-nano-calcium--deficient-hydroxyapatite-mult-a9439https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hong Li1, Min Gong1, Aiping Yang1, Jian Ma2, Xiangde Li3, Yonggang Yan11School of Physical Science and Technology, Sichuan University, Chengdu People&rsquo;s Republic of China; 2Hospital of Stomatology, Tongji University, ShanghaiPeople&rsquo;s Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People&rsquo;s Republic of ChinaBackground and methods: A nano calcium-deficient hydroxyapatite (n-CDHA)-multi(amino acid) copolymer (MAC) composite bone substitute biomaterial was prepared using an in situ polymerization method. The composition, structure, and compressive strength of the composite was characterized, and the in vitro degradability in phosphate-buffered solution and preliminary cell responses to the composite were investigated.Results: The composite comprised n-CDHA and an amide linkage copolymer. The compressive strength of the composite was in the range of 88&ndash;129 MPa, varying with the amount of n-CDHA in the MAC (ranging from 10 wt% to 50 wt%). Weight loss from the composite increased (from 32.2 wt% to 44.3 wt%) with increasing n-CDHA content (from 10 wt% to 40 wt%) in the MAC after the composite was soaked in phosphate-buffered solution for 12 weeks. The pH of the soaking medium varied from 6.9 to 7.5. MG-63 cells with an osteogenic phenotype were well adhered and spread on the composite surface. Viability and differentiation increased with time, indicating that the composite had no negative effects on MG-63 cells.Conclusion: The n-CDHA-MAC composite had good cytocompatibility and has potential to be used as a bone substitute.Keywords: calcium deficient hydroxyapatite, multi(amino acid) copolymer, biocomposite, degradability, cytocompatibilityLi XDMa JGong M,Yang APLi HYan YGDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1287-1295 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li XD Ma J Gong M,Yang AP Li H Yan YG Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
description	Hong Li1, Min Gong1, Aiping Yang1, Jian Ma2, Xiangde Li3, Yonggang Yan11School of Physical Science and Technology, Sichuan University, Chengdu People&rsquo;s Republic of China; 2Hospital of Stomatology, Tongji University, ShanghaiPeople&rsquo;s Republic of China; 3Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People&rsquo;s Republic of ChinaBackground and methods: A nano calcium-deficient hydroxyapatite (n-CDHA)-multi(amino acid) copolymer (MAC) composite bone substitute biomaterial was prepared using an in situ polymerization method. The composition, structure, and compressive strength of the composite was characterized, and the in vitro degradability in phosphate-buffered solution and preliminary cell responses to the composite were investigated.Results: The composite comprised n-CDHA and an amide linkage copolymer. The compressive strength of the composite was in the range of 88&ndash;129 MPa, varying with the amount of n-CDHA in the MAC (ranging from 10 wt% to 50 wt%). Weight loss from the composite increased (from 32.2 wt% to 44.3 wt%) with increasing n-CDHA content (from 10 wt% to 40 wt%) in the MAC after the composite was soaked in phosphate-buffered solution for 12 weeks. The pH of the soaking medium varied from 6.9 to 7.5. MG-63 cells with an osteogenic phenotype were well adhered and spread on the composite surface. Viability and differentiation increased with time, indicating that the composite had no negative effects on MG-63 cells.Conclusion: The n-CDHA-MAC composite had good cytocompatibility and has potential to be used as a bone substitute.Keywords: calcium deficient hydroxyapatite, multi(amino acid) copolymer, biocomposite, degradability, cytocompatibility
format	article
author	Li XD Ma J Gong M,Yang AP Li H Yan YG
author_facet	Li XD Ma J Gong M,Yang AP Li H Yan YG
author_sort	Li XD
title	Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
title_short	Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
title_full	Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
title_fullStr	Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
title_full_unstemmed	Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
title_sort	degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9cd5766750834774a9bf9c3f83a162e3
work_keys_str_mv	AT lixd degradablebiocompositeofnanocalciumdeficienthydroxyapatitemultiaminoacidcopolymer AT maj degradablebiocompositeofnanocalciumdeficienthydroxyapatitemultiaminoacidcopolymer AT gongmyangap degradablebiocompositeofnanocalciumdeficienthydroxyapatitemultiaminoacidcopolymer AT lih degradablebiocompositeofnanocalciumdeficienthydroxyapatitemultiaminoacidcopolymer AT yanyg degradablebiocompositeofnanocalciumdeficienthydroxyapatitemultiaminoacidcopolymer
_version_	1718403399644348416

Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer

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