Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma
Dufies et al. find high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discover that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also find that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor...
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Nature Portfolio
2021
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oai:doaj.org-article:9cd5ec5c631f454a824bec657b006c8d2021-12-02T14:06:19ZPlk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma10.1038/s42003-021-01653-w2399-3642https://doaj.org/article/9cd5ec5c631f454a824bec657b006c8d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01653-whttps://doaj.org/toc/2399-3642Dufies et al. find high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discover that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also find that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.Maeva DufiesAnnelies VerbiestLindsay S. CooleyPapa Diogop NdiayeXingkang HeNicolas NottetWilfried SouleyreauAnais HagegeStephanie TorrinoJulien ParolaSandy GiulianoDelphine BorchielliniRenaud SchiappaBaharia MograbiJessica Zucman-RossiKarim BensalahAlain RavaudPatrick AubergerAndréas BikfalviEmmanuel ChamoreyNathalie Rioux-LeclercqNathalie M. MazureBenoit BeuselinckYihai CaoJean Christophe BernhardDamien AmbrosettiGilles PagèsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Maeva Dufies Annelies Verbiest Lindsay S. Cooley Papa Diogop Ndiaye Xingkang He Nicolas Nottet Wilfried Souleyreau Anais Hagege Stephanie Torrino Julien Parola Sandy Giuliano Delphine Borchiellini Renaud Schiappa Baharia Mograbi Jessica Zucman-Rossi Karim Bensalah Alain Ravaud Patrick Auberger Andréas Bikfalvi Emmanuel Chamorey Nathalie Rioux-Leclercq Nathalie M. Mazure Benoit Beuselinck Yihai Cao Jean Christophe Bernhard Damien Ambrosetti Gilles Pagès Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| description |
Dufies et al. find high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discover that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also find that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression. |
| format |
article |
| author |
Maeva Dufies Annelies Verbiest Lindsay S. Cooley Papa Diogop Ndiaye Xingkang He Nicolas Nottet Wilfried Souleyreau Anais Hagege Stephanie Torrino Julien Parola Sandy Giuliano Delphine Borchiellini Renaud Schiappa Baharia Mograbi Jessica Zucman-Rossi Karim Bensalah Alain Ravaud Patrick Auberger Andréas Bikfalvi Emmanuel Chamorey Nathalie Rioux-Leclercq Nathalie M. Mazure Benoit Beuselinck Yihai Cao Jean Christophe Bernhard Damien Ambrosetti Gilles Pagès |
| author_facet |
Maeva Dufies Annelies Verbiest Lindsay S. Cooley Papa Diogop Ndiaye Xingkang He Nicolas Nottet Wilfried Souleyreau Anais Hagege Stephanie Torrino Julien Parola Sandy Giuliano Delphine Borchiellini Renaud Schiappa Baharia Mograbi Jessica Zucman-Rossi Karim Bensalah Alain Ravaud Patrick Auberger Andréas Bikfalvi Emmanuel Chamorey Nathalie Rioux-Leclercq Nathalie M. Mazure Benoit Beuselinck Yihai Cao Jean Christophe Bernhard Damien Ambrosetti Gilles Pagès |
| author_sort |
Maeva Dufies |
| title |
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| title_short |
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| title_full |
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| title_fullStr |
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| title_full_unstemmed |
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| title_sort |
plk1, upregulated by hif-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9cd5ec5c631f454a824bec657b006c8d |
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