Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS

A simple, rapid and sensitive simultaneous method for validation and determination of Montelukast in rat plasma in the presence of grape and licorice juices has been done by using High Performance Liquid Chromatography–Mass Spectrometry (HPLC/MS). A mixture of (77.5 % methanol, 22.5 % of 0.2% FA in...

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Autores principales:	Mohammed Hamad, Rafif Raad, Eyad Mallah, Zainab Zakaria, Tawfiq Arafat, Wael Abu Dayyih
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	validation lc/ms grape licorice pharmacokinetic montelukast Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/9cd74374f27c47be98b35237702e8309
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spelling	oai:doaj.org-article:9cd74374f27c47be98b35237702e83092021-11-15T06:08:47ZDevelopment and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS2338-94272338-948610.22146/ijp.590https://doaj.org/article/9cd74374f27c47be98b35237702e83092020-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/590https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486A simple, rapid and sensitive simultaneous method for validation and determination of Montelukast in rat plasma in the presence of grape and licorice juices has been done by using High Performance Liquid Chromatography–Mass Spectrometry (HPLC/MS). A mixture of (77.5 % methanol, 22.5 % of 0.2% FA in water) was used as a mobile phase, ACE 5 C8 column (50 X 2.1 mm, 5μ), and a flow rate of 0.1 ml/min were used, the auto-sampler injection volume was 5 microliters, and candesartan was used as an internal standard. According to the result obtained, the precision of predicted measurements for Montelukast was good (mean CV % 0.05) of grape on Montelukast Cmax (163.492 ng/ml ±113.27). Neither licorice gives significant decrease in the Montelukast Cmax (143.861ng/ml ±54.52), its only delay the average Montelukast Cmax to half an hour. Even for the AUC, there were no significant difference between Montelukast alone and Montelukast with grape, and Montelukast with licorice (P>0.05). The kinetic data shows that Montelukast plasma level was the same with both combination of Montelukast and grape, and Montelukast and licorice.Mohammed HamadRafif RaadEyad MallahZainab ZakariaTawfiq ArafatWael Abu DayyihUniversitas Gadjah Madaarticlevalidationlc/msgrapelicoricepharmacokineticmontelukastPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 161-170 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	validation lc/ms grape licorice pharmacokinetic montelukast Pharmacy and materia medica RS1-441
spellingShingle	validation lc/ms grape licorice pharmacokinetic montelukast Pharmacy and materia medica RS1-441 Mohammed Hamad Rafif Raad Eyad Mallah Zainab Zakaria Tawfiq Arafat Wael Abu Dayyih Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS
description	A simple, rapid and sensitive simultaneous method for validation and determination of Montelukast in rat plasma in the presence of grape and licorice juices has been done by using High Performance Liquid Chromatography–Mass Spectrometry (HPLC/MS). A mixture of (77.5 % methanol, 22.5 % of 0.2% FA in water) was used as a mobile phase, ACE 5 C8 column (50 X 2.1 mm, 5μ), and a flow rate of 0.1 ml/min were used, the auto-sampler injection volume was 5 microliters, and candesartan was used as an internal standard. According to the result obtained, the precision of predicted measurements for Montelukast was good (mean CV % 0.05) of grape on Montelukast Cmax (163.492 ng/ml ±113.27). Neither licorice gives significant decrease in the Montelukast Cmax (143.861ng/ml ±54.52), its only delay the average Montelukast Cmax to half an hour. Even for the AUC, there were no significant difference between Montelukast alone and Montelukast with grape, and Montelukast with licorice (P>0.05). The kinetic data shows that Montelukast plasma level was the same with both combination of Montelukast and grape, and Montelukast and licorice.
format	article
author	Mohammed Hamad Rafif Raad Eyad Mallah Zainab Zakaria Tawfiq Arafat Wael Abu Dayyih
author_facet	Mohammed Hamad Rafif Raad Eyad Mallah Zainab Zakaria Tawfiq Arafat Wael Abu Dayyih
author_sort	Mohammed Hamad
title	Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS
title_short	Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS
title_full	Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS
title_fullStr	Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS
title_full_unstemmed	Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS
title_sort	development and validation of montelukast with grape/licorice juices and its application to pharmacokinetic studies by lc/ms
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/9cd74374f27c47be98b35237702e8309
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Development and Validation of Montelukast with Grape/Licorice Juices and its Application to Pharmacokinetic Studies by LC/MS

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