Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1

Step-economical and efficient syntheses of Spongistatin 1 analogs are desirable for the development of potent anti-proliferative agents. Here, the authors report a 22-step synthesis of a D-ring modified Spongistatin 1 analog with retained picomolar potency among a group of C(15) ester derivatives.

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Autores principales:	Linda M. Suen, Makeda A. Tekle-Smith, Kevin S. Williamson, Joshua R. Infantine, Samuel K. Reznik, Paul S. Tanis, Tyler D. Casselman, Dan L. Sackett, James L. Leighton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9cd90a1f6e3547f381fa06dc5d3b6186
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spelling	oai:doaj.org-article:9cd90a1f6e3547f381fa06dc5d3b61862021-12-02T17:33:04ZDesign and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 110.1038/s41467-018-07259-x2041-1723https://doaj.org/article/9cd90a1f6e3547f381fa06dc5d3b61862018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07259-xhttps://doaj.org/toc/2041-1723Step-economical and efficient syntheses of Spongistatin 1 analogs are desirable for the development of potent anti-proliferative agents. Here, the authors report a 22-step synthesis of a D-ring modified Spongistatin 1 analog with retained picomolar potency among a group of C(15) ester derivatives.Linda M. SuenMakeda A. Tekle-SmithKevin S. WilliamsonJoshua R. InfantineSamuel K. ReznikPaul S. TanisTyler D. CasselmanDan L. SackettJames L. LeightonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda M. Suen Makeda A. Tekle-Smith Kevin S. Williamson Joshua R. Infantine Samuel K. Reznik Paul S. Tanis Tyler D. Casselman Dan L. Sackett James L. Leighton Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
description	Step-economical and efficient syntheses of Spongistatin 1 analogs are desirable for the development of potent anti-proliferative agents. Here, the authors report a 22-step synthesis of a D-ring modified Spongistatin 1 analog with retained picomolar potency among a group of C(15) ester derivatives.
format	article
author	Linda M. Suen Makeda A. Tekle-Smith Kevin S. Williamson Joshua R. Infantine Samuel K. Reznik Paul S. Tanis Tyler D. Casselman Dan L. Sackett James L. Leighton
author_facet	Linda M. Suen Makeda A. Tekle-Smith Kevin S. Williamson Joshua R. Infantine Samuel K. Reznik Paul S. Tanis Tyler D. Casselman Dan L. Sackett James L. Leighton
author_sort	Linda M. Suen
title	Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
title_short	Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
title_full	Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
title_fullStr	Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
title_full_unstemmed	Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
title_sort	design and 22-step synthesis of highly potent d-ring modified and linker-equipped analogs of spongistatin 1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9cd90a1f6e3547f381fa06dc5d3b6186
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Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1

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