The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats

This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in a liver ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean albumin levels. 40 rats of mean weight 231.875 g were used in the study. A...

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Autores principales:	Τsompos C., Panoulis C., Τοutouzas K., Triantafyllou A., Ζografos G., Papalois A.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	ischemia u-74389g albumin level reperfusion Medicine R
Acceso en línea:	https://doaj.org/article/9cda36034026499b90f523da8c685c95
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spelling	oai:doaj.org-article:9cda36034026499b90f523da8c685c952021-12-02T19:11:12ZThe Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats0324-175010.1515/amb-2016-0012https://doaj.org/article/9cda36034026499b90f523da8c685c952016-10-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0012https://doaj.org/toc/0324-1750This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in a liver ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean albumin levels. 40 rats of mean weight 231.875 g were used in the study. Albumin levels were measured at 60th min of reperfusion (groups A and C) and at 120th min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted albumin levels by 3.63% ± 0.87% (p = 0.0001). Reperfusion time non-significantly increased the predicted albumin levels by 0.72% ± 1.04% (p = 0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted albumin levels by 2.02% ± 0.54% (p = 0.0005). U-74389G administration whether it interacted or not with reperfusion time has significant decreasing short - term effects on albumin levels. It seems that the antioxidant capacity is associated with albumin catabolism.Τsompos C.Panoulis C.Τοutouzas K.Triantafyllou A.Ζografos G.Papalois A.Sciendoarticleischemiau-74389galbumin levelreperfusionMedicineRENActa Medica Bulgarica, Vol 43, Iss 2, Pp 11-20 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ischemia u-74389g albumin level reperfusion Medicine R
spellingShingle	ischemia u-74389g albumin level reperfusion Medicine R Τsompos C. Panoulis C. Τοutouzas K. Triantafyllou A. Ζografos G. Papalois A. The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats
description	This experimental study examined the effect of the antioxidant drug U-74389G on a rat model and particularly in a liver ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean albumin levels. 40 rats of mean weight 231.875 g were used in the study. Albumin levels were measured at 60th min of reperfusion (groups A and C) and at 120th min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted albumin levels by 3.63% ± 0.87% (p = 0.0001). Reperfusion time non-significantly increased the predicted albumin levels by 0.72% ± 1.04% (p = 0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted albumin levels by 2.02% ± 0.54% (p = 0.0005). U-74389G administration whether it interacted or not with reperfusion time has significant decreasing short - term effects on albumin levels. It seems that the antioxidant capacity is associated with albumin catabolism.
format	article
author	Τsompos C. Panoulis C. Τοutouzas K. Triantafyllou A. Ζografos G. Papalois A.
author_facet	Τsompos C. Panoulis C. Τοutouzas K. Triantafyllou A. Ζografos G. Papalois A.
author_sort	Τsompos C.
title	The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats
title_short	The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats
title_full	The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats
title_fullStr	The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats
title_full_unstemmed	The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats
title_sort	effect of the antioxidant drug u-74389g on albumin levels during ischemia reperfusion injury in rats
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/9cda36034026499b90f523da8c685c95
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The Effect of the Antioxidant Drug U-74389G on Albumin Levels during Ischemia Reperfusion Injury in Rats

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