Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Novoyatleva et al investigate the role of receptor tyrosine kinase Axl in Pulmonary arterial hypertension (PAH), finding that the small molecule inhibitor R428 reduces human pulmonary arterial smooth muscle cells proliferation and migration, but causes toxicity in human pulmonary arterial endothelia...

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Autores principales:	Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D. Upton, Sonja Loges, Nicholas W. Morrell, Werner Seeger, Ralph T. Schermuly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9cdae1283c834b96804aa01aec8d92af
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spelling	oai:doaj.org-article:9cdae1283c834b96804aa01aec8d92af2021-12-02T15:09:22ZDeficiency of Axl aggravates pulmonary arterial hypertension via BMPR210.1038/s42003-021-02531-12399-3642https://doaj.org/article/9cdae1283c834b96804aa01aec8d92af2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02531-1https://doaj.org/toc/2399-3642Novoyatleva et al investigate the role of receptor tyrosine kinase Axl in Pulmonary arterial hypertension (PAH), finding that the small molecule inhibitor R428 reduces human pulmonary arterial smooth muscle cells proliferation and migration, but causes toxicity in human pulmonary arterial endothelial cells. They further show that Axl enhances endothelial BMPR2 signaling, altogether providing insights into mechanisms of PAH.Tatyana NovoyatlevaNabham RaiBaktybek KojonazarovSwathi VeerojuIsabel Ben-BatallaPaola CarusoMazen ShihanNadine PresserElsa GötzCarina LepperSebastian HerpelGrégoire ManaudFrédéric PerrosHenning GallHossein Ardeschir GhofraniNorbert WeissmannFriedrich GrimmingerJohn WhartonMartin WilkinsPaul D. UptonSonja LogesNicholas W. MorrellWerner SeegerRalph T. SchermulyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tatyana Novoyatleva Nabham Rai Baktybek Kojonazarov Swathi Veeroju Isabel Ben-Batalla Paola Caruso Mazen Shihan Nadine Presser Elsa Götz Carina Lepper Sebastian Herpel Grégoire Manaud Frédéric Perros Henning Gall Hossein Ardeschir Ghofrani Norbert Weissmann Friedrich Grimminger John Wharton Martin Wilkins Paul D. Upton Sonja Loges Nicholas W. Morrell Werner Seeger Ralph T. Schermuly Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
description	Novoyatleva et al investigate the role of receptor tyrosine kinase Axl in Pulmonary arterial hypertension (PAH), finding that the small molecule inhibitor R428 reduces human pulmonary arterial smooth muscle cells proliferation and migration, but causes toxicity in human pulmonary arterial endothelial cells. They further show that Axl enhances endothelial BMPR2 signaling, altogether providing insights into mechanisms of PAH.
format	article
author	Tatyana Novoyatleva Nabham Rai Baktybek Kojonazarov Swathi Veeroju Isabel Ben-Batalla Paola Caruso Mazen Shihan Nadine Presser Elsa Götz Carina Lepper Sebastian Herpel Grégoire Manaud Frédéric Perros Henning Gall Hossein Ardeschir Ghofrani Norbert Weissmann Friedrich Grimminger John Wharton Martin Wilkins Paul D. Upton Sonja Loges Nicholas W. Morrell Werner Seeger Ralph T. Schermuly
author_facet	Tatyana Novoyatleva Nabham Rai Baktybek Kojonazarov Swathi Veeroju Isabel Ben-Batalla Paola Caruso Mazen Shihan Nadine Presser Elsa Götz Carina Lepper Sebastian Herpel Grégoire Manaud Frédéric Perros Henning Gall Hossein Ardeschir Ghofrani Norbert Weissmann Friedrich Grimminger John Wharton Martin Wilkins Paul D. Upton Sonja Loges Nicholas W. Morrell Werner Seeger Ralph T. Schermuly
author_sort	Tatyana Novoyatleva
title	Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
title_short	Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
title_full	Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
title_fullStr	Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
title_full_unstemmed	Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
title_sort	deficiency of axl aggravates pulmonary arterial hypertension via bmpr2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9cdae1283c834b96804aa01aec8d92af
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Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

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