Enhancing mucosal immunity by transient microbiota depletion

Tissue resident CD8 + T cells present at mucosal surfaces are poised to elicit function in situ, however approaches to boost their number in the gastrointestinal mucosa has been limited. Here the authors combine the use of Listeria monocytogenese and transient depletion of the intestinal microbiome...

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Autores principales:	Simone Becattini, Eric R. Littmann, Ruth Seok, Luigi Amoretti, Emily Fontana, Roberta Wright, Mergim Gjonbalaj, Ingrid M. Leiner, George Plitas, Tobias M. Hohl, Eric G. Pamer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9cddbe7fed714fe98fcf6304ce6172f0
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spelling	oai:doaj.org-article:9cddbe7fed714fe98fcf6304ce6172f02021-12-02T19:12:34ZEnhancing mucosal immunity by transient microbiota depletion10.1038/s41467-020-18248-42041-1723https://doaj.org/article/9cddbe7fed714fe98fcf6304ce6172f02020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18248-4https://doaj.org/toc/2041-1723Tissue resident CD8 + T cells present at mucosal surfaces are poised to elicit function in situ, however approaches to boost their number in the gastrointestinal mucosa has been limited. Here the authors combine the use of Listeria monocytogenese and transient depletion of the intestinal microbiome to boost the resident CD8 + T cell response.Simone BecattiniEric R. LittmannRuth SeokLuigi AmorettiEmily FontanaRoberta WrightMergim GjonbalajIngrid M. LeinerGeorge PlitasTobias M. HohlEric G. PamerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simone Becattini Eric R. Littmann Ruth Seok Luigi Amoretti Emily Fontana Roberta Wright Mergim Gjonbalaj Ingrid M. Leiner George Plitas Tobias M. Hohl Eric G. Pamer Enhancing mucosal immunity by transient microbiota depletion
description	Tissue resident CD8 + T cells present at mucosal surfaces are poised to elicit function in situ, however approaches to boost their number in the gastrointestinal mucosa has been limited. Here the authors combine the use of Listeria monocytogenese and transient depletion of the intestinal microbiome to boost the resident CD8 + T cell response.
format	article
author	Simone Becattini Eric R. Littmann Ruth Seok Luigi Amoretti Emily Fontana Roberta Wright Mergim Gjonbalaj Ingrid M. Leiner George Plitas Tobias M. Hohl Eric G. Pamer
author_facet	Simone Becattini Eric R. Littmann Ruth Seok Luigi Amoretti Emily Fontana Roberta Wright Mergim Gjonbalaj Ingrid M. Leiner George Plitas Tobias M. Hohl Eric G. Pamer
author_sort	Simone Becattini
title	Enhancing mucosal immunity by transient microbiota depletion
title_short	Enhancing mucosal immunity by transient microbiota depletion
title_full	Enhancing mucosal immunity by transient microbiota depletion
title_fullStr	Enhancing mucosal immunity by transient microbiota depletion
title_full_unstemmed	Enhancing mucosal immunity by transient microbiota depletion
title_sort	enhancing mucosal immunity by transient microbiota depletion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9cddbe7fed714fe98fcf6304ce6172f0
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Enhancing mucosal immunity by transient microbiota depletion

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